Meds
SE / Nursing Actions
Priority + Meds
Diagnosis?
Red Flags
100

A patient receiving chemotherapy is given a medication prior to treatment to prevent nausea and vomiting. The nurse monitors for QT prolongation. Which medication is this?

Ondansetron

  • What it does: 5-HT3 blocker → prevents chemo N/V
  • Key risk: QT prolongation
  • Nursing: monitor EKG if high risk
100

A patient receiving chemotherapy is given ondansetron and later reports a mild headache and constipation. What is the appropriate nursing action?

Continue medication and monitor

  • These are expected side effects
  • Only escalate if severe or cardiac symptoms 
100

A patient receiving chemotherapy is scheduled to receive ondansetron prior to treatment. The patient reports mild nausea but is otherwise stable. What is the nurse’s FIRST action?

Administer ondansetron as ordered

  • Preventive antiemetics are standard before chemo
  • Don’t wait for severe symptoms
100

A patient receives ondansetron prior to chemotherapy and reports nausea relief but later requires continued antiemetic support during treatment. What condition is being managed?

Chemotherapy-induced nausea and vomiting (CINV)

  • Clue: prophylactic ondansetron use
100

A patient receiving ondansetron reports mild constipation and headache. What is the priority action?

Continue medication and monitor

  • Expected side effects
  • NOT a red flag
200

A patient undergoing chemotherapy develops severe bone pain after starting a medication to increase white blood cell production. Which medication is this?

Filgrastim

  • What it does: stimulates neutrophil production
  • Key risk: bone pain
  • Nursing: used for neutropenia, monitor WBC
200

A patient receiving filgrastim reports severe bone pain. What is the best nursing response?


Administer prescribed analgesics and continue therapy

  • Bone pain is expected due to bone marrow stimulation
  • NOT a reason to stop the med
200

A patient receiving chemotherapy has an ANC of 500 and a temperature of 101°F. The provider has ordered filgrastim. What is the nurse’s FIRST action?

Initiate neutropenic precautions and notify provider

  • Infection is the immediate life threat
  • Filgrastim helps, but infection control is priority
200

A patient receiving chemotherapy is started on filgrastim after labs show a critically low neutrophil count. What condition is being treated?

Neutropenia

  • Clue: filgrastim → increases neutrophils
200

A patient receiving filgrastim reports severe bone pain but has stable vital signs and labs. What is the priority action?

Administer analgesics and continue therapy

  • Expected side effect
  • Not dangerous
300

A patient receiving chemotherapy develops mouth sores, diarrhea, and low blood counts. The provider suspects toxicity from a medication that interferes with DNA synthesis. Which medication is most likely responsible?

5-Fluorouracil (5-FU)

  • What it does: antimetabolite → blocks DNA synthesis
  • Key risks: mucositis, diarrhea, bone marrow suppression
  • Nursing: oral care, monitor CBC
300

A patient receiving vincristine develops progressive numbness in the hands and feet and has not had a bowel movement in 3 days. What is the priority nursing action?

Notify provider and assess for worsening neuropathy/constipation

  • Neurotoxicity can become severe
  • Risk of ileus → this is NOT just expected, needs escalation
300

A patient receiving vincristine reports worsening numbness and has not had a bowel movement in several days. What is the nurse’s FIRST action?

Assess bowel function and notify provider

  • Risk of ileus + worsening neurotoxicity
  • Needs intervention before giving more medication
300

A patient receiving vincristine develops:

  • numbness/tingling
  • decreased reflexes
  • constipation

What condition is most likely occurring?

Peripheral neuropathy (chemo-induced neurotoxicity)

  • Clue: classic vincristine side effect cluster
300

A patient receiving vincristine develops:

  • worsening numbness
  • no bowel movement for 4 days
  • abdominal distention

What is the red flag and action?

Suspected ileus → hold medication and notify provider

  • Neurotoxicity affecting GI motility
  • Can become life-threatening
400

A patient receiving chemotherapy develops numbness/tingling in the hands and feet along with constipation. Which medication is causing this, and what is the priority concern?

Vincristine

  • What it does: inhibits cell division
  • Key risks: peripheral neuropathy, constipation
  • Nursing: neuro checks, bowel monitoring
400

A patient on doxorubicin develops new fatigue, dyspnea, and mild edema. What is the priority nursing action?

Hold medication and notify provider → evaluate cardiac function

  • Suspected cardiotoxicity
  • This is a serious complication
400

A patient receiving cisplatin is due for their next dose. Labs show elevated creatinine. What is the nurse’s FIRST action?

Hold the medication and notify provider

  • Nephrotoxicity risk
  • Do NOT administer
400

A patient receiving doxorubicin develops:

  • fatigue
  • shortness of breath
  • decreased exercise tolerance

What is the MOST likely diagnosis?

Chemotherapy-induced cardiomyopathy (heart failure)

  • Clue: doxorubicin = cardiotoxic
400

A patient receiving doxorubicin develops:

  • shortness of breath
  • fatigue
  • new edema

What is the red flag and action?

Cardiotoxicity → hold medication and notify provider immediately

  • Risk of heart failure
  • Requires cardiac evaluation
500

A patient receiving chemotherapy develops:

  • shortness of breath
  • fatigue
  • decreased exercise tolerance

The provider is concerned about cumulative toxicity. Which medication is most likely responsible, and what must be monitored?

Doxorubicin

  • What it does: anthracycline chemo
  • Key risk: cardiotoxicity (heart failure)
  • Nursing: monitor cardiac function (EF), lifetime dose limits 
500

A patient receiving cisplatin has:

  • rising creatinine
  • decreased urine output
  • reports ringing in ears

What is the priority nursing action?

Hold medication and notify provider immediately

  • Nephrotoxicity + ototoxicity
  • Can become irreversible if not addressed
500

A patient receiving doxorubicin develops:

  • shortness of breath
  • fatigue
  • decreased exercise tolerance

The next dose is due. What is the nurse’s FIRST action?

Hold the medication and notify provider → cardiac evaluation

  • Suspected cardiotoxicity
  • Giving another dose could worsen heart failure
500

A patient receiving cisplatin develops:

  • rising creatinine
  • decreased urine output
  • tinnitus

What is the MOST likely diagnosis?

Nephrotoxicity with ototoxicity

  • Clue: cisplatin affects kidneys + ears
500

 patient receiving cisplatin develops:

  • rising creatinine
  • decreased urine output
  • hearing changes

What is the red flag and action?

Nephrotoxicity + ototoxicity → hold medication and notify provider immediately

  • Can become irreversible
  • Requires urgent intervention
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