Excipients
This excipient fills the empty space and increases the accuracy of our capsule. We are using lactose for ours.
What is diluent?
When hand-filling capsules, this is the part of the capsule that the powder should be packed in.
What is the body?
When compounding capsules today, you should account for this many excess capsules.
What is 2?
This is what our hydrochlorothiazide capsules are being used to treat.
What is high blood pressure?
Choice of capsule size is dependent on the amount of this needed in each capsule.
What is active drug?
This excipient is added as a quality assurance measure (visible test) and must be pharmacologically inactive.
What is a coloring agent?
This pure drug source must be crushed prior to compounding it into a capsule.
What is a tablet?
The amount of total drug that you would need if you were given this prescription and were told to make 1 extra capsule. Source is losartan 10 mg tablets.
Losartan 22 mg M. FT. Cap, D.T.D #6
Lactose QS SIG: 1 PO QAM
What is 154 mg?
This is when the patient should be taking hydrochlorothiazide due to a potential side effect.
What is in the morning?
Per USP <795>, this is the maximum beyond use date for a nonaqueous solid dosage form.
What is 180 days?
This excipient reduces powders from sticking to surfaces and/or itself. Magnesium stearate is a common one.
What is a flow agent?
This is the largest capsule size that can be used orally for humans, and may even be too large to swallow for some patients.
What is 00?
This is the amount of lisinopril tablets needed to supply enough drug, given we need 42 mg of lisinopril and our tablet source is lisinopril 10 mg.
What is 5 tablets?
This can be monitored by patients at home while they are taking HCTZ.
What is blood pressure?
People allergic to this class of medications may have a reaction when taking hydrochlorothiazide.
What are sulfa drugs?
This type of powder is usually avoided as a diluent when compounding capsules because it may form thick, viscous barriers around drug particles when exposed to stomach fluid, preventing drug release.
What are natural and synthetic gum powders?
This type of release formulation can be accomplished by poking holes in a capsule.
What is rapid-release?
This is the amount of diluent needed to make 8 capsules (522 mg required tablet weight) and a goal capsule weight of 365 mg/capsule.
What is 2,398 mg?
This is how the compounded HCTZ capsule should be packaged and stored.
What is in a well-closed container at CRT?
Hydrochlorothiazide inhibits sodium reabsorption in this part of the nephron, causing increased excretion of sodium and water.
What is the distal convoluted tubule?
This material can not be encapsulated because it can make a capsule brittle.
What is a deliquescent material?
This capsule type is designed to release drugs rapidly or over a predetermined time.
What is a hard-shelled capsule?
This is the amount of throw away tablet powder given the following.
Using 7 tablets weighing 105 mg/tablet. Need 6.5 tablets for compound.
What is 52.5 mg?
Depending on the medication, and with prior approval from a pharmacist or doctor, this can be done to some capsules if they cannot be swallowed whole.
What is open up and mix contents with food or water?
Hypotension can present with similar symptoms to this other condition and can often be confused for it if further testing is not completed.
What is hypoglycemia?