Cologuard/Plus
What year, did ACS and CMS guidance require coverage to encourage CRC screening by reducing financial barriers?
2023.
For stomach, ovarian, and liver cancers, Cancerguard achieved sensitivities ranging as high as what percentages?
71.4% to 80%.
What are the SimpleScreen CRC sensitivity, specificity, and sensitivity for advanced precancerous lesions (APLs)?
81% sensitivity, 90% specificity, and 14% sensitivity for APLs.
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New cancer cases are predicted to increase to how many million worldwide by 2050?
35 million.
True or False: Colorectal cancer is the third most common cancer among men and women.
True. Good Job, since you got this question correct please select a person from your team to play a mini game for a chance at extra points.
What is the advanced precancerous lesion (APL) sensitivity for Cologuard Plus, and how did it compare with FIT?
43.3% (849/1,962) for Cologuard Plus versus 23.3% for FIT.
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Cancerguard is not intended for screening of which two cancers and has not been evaluated for detection of precancerous lesions?
Breast and prostate cancers.
How often can SimpleScreen be taken?
In the Cancerguard clinician brochure, non-Hodgkin lymphoma was listed within a cancer subgroup. How many lymphoma samples were tested in the study?
Zero samples were obtained.
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Over a 10-year span, three Cologuard Plus tests detected what percentage more precancerous lesions and CRC cases?
13% more precancerous lesions and 11% more CRC cases. Good Job, since you got this question correct please select a person from your team to play a mini game for a chance at extra points.
How many biomarkers does the original Cologuard analyze compared with Cologuard Plus?
Original Cologuard uses 11 biomarkers: 10 altered-DNA biomarkers and 1 hemoglobin biomarker. Cologuard Plus uses 5 biomarkers, including DNA methylation and hemoglobin.
Which of the four main components of blood does Cancerguard analyze, and why? + mini game
Plasma, because this is where circulating tumor DNA (ctDNA) is found within the blood.
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What type of patient should consider SimpleScreen CRC instead of Cologuard?
A hard-to-screen, average-risk patient age 45 or older who has declined other screening options.
What are the six kit components of the Cancerguard kit?
Four LBguard blood tubes, instructions for use, tube labels, an absorbent sleeve, two gel packs, and a biohazard bag.
Define sensitivity and specificity.
Sensitivity is the proportion of people with the disease who have a positive test result (true positive). Specificity is the proportion of people without the disease who have a negative test result (true negative).
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Cologuard Plus detected how many times more precancerous lesions and sessile serrated lesions than FIT?
2x more precancerous lesions and 10x more sessile serrated lesions.
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What is the overall sensitivity for Cancerguard, and what is the sensitivity across the six high-mortality cancers?
64% overall, excluding breast and prostate cancers, and 68% across the six high-mortality cancers .
What are the two processes for completing SimpleScreen, and how do they work?
Provider Managed: on-site blood draw supported by stocked kits. The provider orders the test, blood is drawn in the office or a central lab, the sample is returned for analysis, and results are delivered based on the order method.
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What does the acronym HEDIS stand for, and what does HEDIS credit mean?
Healthcare Effectiveness Data and Information Set. The source document describes HEDIS credit as performance measurement criteria in which health plans may receive a binary score, such as full credit or no credit, for meeting particular reporting standards.
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What is the negative predictive value (NPV) for Cologuard Plus, and what does it mean?
99.9%, With a negative result, there was 99% certainty that a patient would not have CRC. Good Job you get to play a mini game.
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If a patient recently had another colorectal cancer screening test, how long must they wait before being eligible for Cologuard Plus, and does the waiting period differ by test type?
Yes per the clinicians CG plus brochure, The waiting period varies by prior test type: 6 months after a positive result from another CRC screening method in general, 12 months after an FOBT or FIT, and 36 months after a FIT-DNA test.
What are the six high-mortality cancers with the shortest five-year survival rates?
Esophageal, liver, lung, ovarian, pancreatic, and stomach cancers.
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What are the labeled precautions for SimpleScreen?
Blood-based tests should only be recommended for people who decline and will not complete an ACS-preferred screening method. Patients who complete a blood-based CRC screening method should be aware of its limited ability to detect APLs and stage I CRC.
What potential allergy risk is noted after a positive Cancerguard result?
Iodine.
After a positive Cologuard test, what percentage of patients adhered to a follow-up colonoscopy within one year?
77%.
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