Diagnostics
This lab is typically elevated in hemophilia A.
What is aPTT?
The most common inherited bleeding disorder.
What is Von Willebrand disease?
This medication stimulates release of stored vWF and factor VIII.
What is Desmopressin (DDAVP)?
Primary hemostasis mainly involves these cells.
What are platelets?
A child presents with recurrent nosebleeds, gum bleeding, and menorrhagia. The bleeding pattern suggests this type of hemostatic defect.
What is a platelet/primary hemostasis disorder?
A prolonged PT that corrects on mixing study suggests this type of problem.
What is a factor deficiency?
Hemophilia B is caused by deficiency of this factor.
What is Factor IX?
This blood product contains concentrated fibrinogen, factor VIII, factor XIII, and vWF.
What is Cryoprecipitate?
This platelet receptor binds von Willebrand factor during adhesion.
What is GpIb?
A teenage boy develops painful swollen knees after sports with prolonged aPTT. This diagnosis is most likely.
What is Hemophilia A or B?
This coagulation factor is evaluated primarily by PT/INR.
What is Factor VII?
This vitamin deficiency commonly prolongs PT first before affecting aPTT.
What is Vitamin K deficiency?
This is the preferred treatment for acute bleeding in hemophilia A.
What is Factor VIII concentrate?
Secondary hemostasis ultimately produces this protein mesh.
What is fibrin?
Persistent bleeding after circumcision in a newborn male should raise concern for this category of disease.
What is an inherited bleeding disorder (especially hemophilia)?
A patient has normal platelet count, prolonged aPTT, and recurrent hemarthroses. The most likely diagnosis category is this.
What is a coagulation factor disorder (hemophilia)?
This subtype of von Willebrand disease is usually the most severe and may resemble hemophilia.
What is Type 3 von Willebrand disease?
This antifibrinolytic medication is commonly used for mucosal bleeding and menorrhagia.
What is Tranexamic acid?
This endogenous anticoagulant inactivates factors Va and VIIIa.
What is Protein C (with Protein S)?
Petechiae and purpura are more commonly associated with disorders involving this component of hemostasis.
What are platelets?
Failure of a prolonged aPTT to correct after mixing study suggests this.
What is an inhibitor or anticoagulant presence (e.g., lupus anticoagulant, factor VIII inhibitor)?
This inherited bleeding disorder commonly presents with hemarthroses and is X-linked recessive.
What is Hemophilia A or B?
This major complication can develop after repeated factor replacement in hemophilia patients and makes treatment less effective.
What is factor inhibitor development?
This molecule inhibits platelet aggregation and is released by intact endothelium.
What is prostacyclin (PGI2)?
A patient with cirrhosis presents with bruising, elevated PT and aPTT, thrombocytopenia, and low fibrinogen. The underlying mechanism is this.
What is impaired hepatic synthesis of clotting factors with consumptive/coagulopathic dysfunction?