Adrenal Gland function
What is produced by the Zona Fasiculata?
Glucocorticoids
name for the symptoms resulting from acid hypersecretion from gastrin secreting tumors in GI tract
Zollinger Ellison syndrome
type of cells a pheochromocytoma comes from
chromaffin
<=-2.5 T score on Dexa scan indicates
osteoporosis
Which amino acid is the basis for epinephrine
Tyrosine
There is increased ___________ activity with 21 hydroxylase deficiency in response to reduced blood pressure
renin
Pharmacological treatment for glucagonoma
octreotide
Disorder associated with Cafe au lait spots, intellectual disability, optic gliomas, pheo, bone lesions and is due to a mutation to a tumor suppresor gene on chromosome 17 that encodes for a negative RAS regulator
Neurofibromatosis type 1 (neurofibromin)
Homer wright rosettes (cluster of blue neuroblasts in a ring) are indicitave of what in a patient with a firm irregular abdominal mass that doesn't cross the midline
neuroblastoma
tapping of the fasical nerve leading to contraction of facial muscles, associated with hypoparathyroidism
chvostek sign
Enzyme that catalyzes the formation of corticosterone from 11-deoxycorticosterone and the formation of cortisol from deoxycortisol
11B-hydroxylase
Excess serotonin production in Carcinoid tumor depletes ______ leading to pellagra
tryptophan
Tuberous sclerosis complex is an autosomal dominant disorder associated with utations on chromosome 9 for _______________ and on chromocome 16 for tuberin
hamartin
Bug most highly associated with Waterhouse Friederichsen syndrome
Neisseria meningtidis
Catecholamine only produced by the medulla
Epinephrine
Agent commonly found in a type of candy, that prevents the formation of Cortisone from cortisol
glycyrrhetinic acid
dermatitic finding associated with tumor of pancreatic alpha cells
necrolytic migratory erythema
VHL ubiquinates ____________ absence of VHL by deletion on chromosome 3 leads to VHL disease
Hypoxia inducible factor 1a
Oncogene associated with neuroblastoma
N-Myc
molecular markers stained for to determine pheochromocytoma (name at least 1)
chromogranin, synaptophysin, NSE
Decreased levels of _____________ are characteristic of 17-alpha-hydroxylase deciciency. This molecule will lead to the eventual produciton of testosterone, estradiol or DHT.
Androstenedione
In carinoid tumors there is often elevated levels of urinary _____________ which is useful in diagnosis
5-HIAA
Condition associated with port-wine stain with seizures, epilepsy and early glaucoma among other symptoms
Sturge-Weber Syndrome (GNAQ gene)
Neurotransmitter that Relaxes intestinal smooth muscle and sphincters,pancreatic bicarbonate secretion, increases waterand electrolyte secretion, and inhibit gastric acidsecretion
VIP
Gene associated with autosomal dominant maternally transmitted mutation leading to inactivation of adenylate cyclase when PTH binds its resceptor leading to resistance to PTH
GNAS 1