Labs/Tests
preferred initial screening test
IgA anti–tissue transglutaminase antibodies
Name one common vitamin deficiency associated with celiac disease
Vitamin D disease (deficiency of vitamin A, B12, D, E, K, copper, zinc, folic acid, and iron can also occur)
Most gender and age group diagnosed with celiac
women 10 and 40 years.
Most common reason for refractory Celiac Disease
non-adherence to diet
Gold standard for diagnosis of celiac disease
upper endoscopy with duodenal biopsy
Commonly Causes this type of anemia (not chronic disease)
Iron deficiency anemia
Common Histological changes to the kidneys
Glomerular IgA deposition
Refractory Celiac disease is treated with what type of medication
Histological findings with Celiac Disease on biopsy
increased intraepithelial lymphocytes, to a severely atrophic mucosa with complete loss of villi, enhanced epithelial apoptosis, and crypt hyperplasia (Villous blunting/atrophy is acceptable)
Name the skin condition that involves a blistering rash with pathognomonic cutaneous IgA deposits
Dermatitis herpetiformis
Genetic disorders resulting from chromosomal abnormalities that are at higher risk for developing Celiac disease
Down and Turner syndromes
Medication to maintain remission after induction with corticosteroids in pts with refractory celiac disease
Azathioprine
IGA deficiency is more common in patients with Celiac Disease. What is the preferred serologic lab in this circumstance
DGP-IgG (Anti-deamidated gliadin peptide)
Name 3 autoimmune conditions associated with celiac
Type 1 diabetes, Hashimoto thyroiditis, PBC, PSC, Addison disease
On physical exam, what might be noted in the HEENT section of physical exam
Atrophic glossitis
Treatment of dermatitis herpetiformis if there is incomplete response despite gluten free diet
Dapsone
haplotype expressed in the majority of patients with celiac disease
HLA-DQ2 and 8
Most common Cancer associated with celiac disease
Enteropathy-associated T-cell lymphoma
Two childhood viral infections that can increase the risk of celiac disease?
Adenovirus and rotavirus
Vaccination recommended in patient's with Celiac Disease and Why?
Pneumococcal/hyposplenism