What happens in mitosis stays in mitosis
At this stage of Mitosis, chromosomes condense.
What is Prophase?
This protein plays a role in promoting degradation of cyclin.
What is anaphase promoting complex (APC)?
During development, cells that are not needed (like those between fingers or toes) are removed by this process.
What is apoptosis?
Studies using this model system identified mitosis promoting factor (MPF).... Ribbit!
What is Xenopus?
How many cell cycle phases do fission yeast go through?
What is 4? (G1, S, G2, M)
When sister chromatids seperate
What is Anaphase?
Anaphase promoting complex (APC) is this type of enzyme
What is ubiquitin ligase?
The molecular machinery responsible for apoptosis involves this family of proteins.
What is caspases?
Tim Hunt named the protein he discovered in sea urchin eggs "cyclin" because of his love of cycling and also because of this distinct feature of the protein.
What is changes in proten level?
Fission yeast have how many Cdks?
What is one?
Breakdown of nuclear envelope occurs
What is Prometaphase?
Sister chromatids are physically linked together with the help of this protein.
What is cohesin?
Reduced caspase activity can be found in what type of cells?
What is cancer cells?
Paul Nurse used this type of fission yeast mutant to identify cell cycle genes.
What is temperature sensitive?
Damien Coudreuse and Paul Nurse found that these 2 proteins fused together could drive the cell cycle - even in the absence of many other players.
What is Cdc13/cyclin and Cdk?
What is Anaphase?
This protein cleaves cohesion complexes allowing the mitotic spindle to pull apart sister chromatids
What is separase?
Initiator caspases promote apoptosis by this mechanism?
Deletion of wee1 leads to this cell size compared to wildtype?
What is small?
In large cells this protein accumulates in the nucleus to activate Cdk-cyclin and promote entry into mitosis.
What is Cdc25?
Nuclear envelope reassembles
What is telophase?
This protein inhibits separase prior to anaphase
What is securin?
Bax and Bak trigger apoptosis by releasing this from the mitochondria
What is Cytochrome C?
Shifting Cdc25 temperature sensitive mutants to the non-permissive temperature leads to this cell size phenotype?
What is large cell size?
Coudreuse and Nurse found that this regulation (while not essential for cell cycle progression in the presence of the fusion protein) might make the cell cycle control system more accurate.
What is phosphorylation?