Mitotic Cyclin/Cdk
Mitotic cyclin/cdks cause this transition in the cell cycle.
What is the G2 to M transition?
The anaphase promoting complex causes this transition in the cell cycle.
What is the metaphase to anaphase transition?
Rb is activated by _____.
What is dephosphorylation?
p53 is inhibited by the binding of _____.
What is Mdm2?
Mitotic cylin/cdks are activated in these two ways.
What are activating kinases, and phosphatases that remove inhibiting phosphates?
The anaphase promoting complex has these two targets.
What is mitotic cyclin and securin?
Rb is inhibited by _____.
What is phosphorylation?
p53 has these two targets.
What is p21 and Puma?
Mitotic cyclin/cdks are inhibited in these two ways.
What is DNA damage and inhibiting kinases?
The anaphase promoting complex is inhibited by this process.
What is mad and bub sequestering cdc20 when chromatids remain unattached to the mitotic spindle?
Rb's target is _____.
What is E2F?
p53 is activated by _____ from _____ in response to _____.
What is phosphorylation, ATM, and DNA damage?
Mitotic cyclin/cdks target these four areas.
What are lamins, condensins, microtubule associated protiens, and the anaphase promoting complex?
The anaphase promoting complex is activated in these two ways.
What is the presence of mitotic cyclin/cdk and the binding of cdc20?
Rb causes this halt in the cell cycle.
What is no G1 to S transition (G1 arrest)?
Depending on the target, p53 has these two effects on the cell cycle.
What is G1 arrest and apoptosis?
Mitotic cyclin/cdks have these effects on their four targets.
What is nuclear envelope breakdown, chromosome condensation, mitotic spindle formation, and cyclin degradation?
The anaphase promoting complex has these effects on its targets.
What is chromosome de-condensation, reformation of the nuclear envelope, spindle disassembly, and the freeing of seperase to cleave cohesin?
Rb has this effect on its target.
What is the prevention of E2F from transcribing S-phase genes?
p53 has these effects on its two targets.
What is the inhibition of cyclin/cdks preventing Rb phosphorylation, and the inhibition of Bcl-2?