MOAs
Stimulates beta 2 adrenergic receptors to relax airways. Can simultaneously stimulate beta 1 receptors.
Beta-agonist
Anorexia, tachycardia, palpitations, N/V, dysrhythmias
Xanthine
Xanthines
mild- mod asthma
adjunction to COPD management
NOT FOR ACUTE
Albuterol (proventil)
Beta-agonists(bronchodilators)
SABA
for acute bronchospasm
may cause anxiety, increase HR, angina, tremors
Fluticasone propionate (Flonase)
corticosteroid
Nasally
Decreases inflammation and enhances beta-agonist activity.
Corticosteroids
Dry mouth, nasal congestion, headache, anxiety, urinary retention+hesitation, constipation
Anticholinergics
Beta-agonists
Relief of bronchospasm
hypotension/shock
Salmeterol (serevent Diskus)
beta-agonist (bronchodilators)
LABA
for prevention/maintenance
2x per day with an inhaled corticosteroid
Fluticasone propionate (flovent)
MDI - inhaler
Decreases inflammation and prevents smooth muscle contraction. Prevents formation of leukotrienes.
LTRA
Sore throat, coughing, dry mouth, oral fungal infection
Corticosteroids
Corticosteroids
inflammation from constriction in asthma and COPD. Take SABA b4 this.
Ipratropium (Atrovent)
Anticholinergic (bronchodilators)
allergy contraindicated!
inhaled
used with beta 2 agonists
Fluticasone with salmeterol
Combined inhaler makes Advair
Blocks ACh receptors and prevents bronchoconstriction.
Anticholinergics
Cardiac stimulation, hyperglycemia, anorexia, insomnia, restlessness, tremor, headache
Beta-agonist
LTRA
Long term treatment
decreasing inflammation and mucus
relaxing airways
Theophylline
Xanthine (bronchodilators)
Don't give/take with caffeine!!
therpatutic @ 10-20 mcg/mL
can cause anorexia
Methylprednisolone
systemic corticosteroid
oral and IV
NOT INTRANASAL
Causes bronchodilation by increasing cAMP(it relaxes smooth muscles and stops allergic reaction mediators. Can also stimulate CNS to enhance respiratory drive.
Xanthine
Anticholinergics
Bronchospasms from COPD
Montelukast (singulair)
LTRA (non bronchodilating)
only given oral and once a day!
For maintenance
Black box warning for mood changes