Hemostasis
Define Fibrinolysis
Process of dissolving the clot
What is the reference range for PT (in seconds)?
10-13 seconds
What specimen would you collect a coagulation test on? What ratio of blood to anticoagulant?
3.2% sodium citrate (blue top tube)
9:1 ratio
Classes of Immunoglobulins
IgG, IgM, IgA, IgD, IgE
What are 5 general health requirements to donate blood?
Weight 110 lbs
Age 16 years
Temp < 99.5 degs F
BP <180/100
Hgb >11g/dL or 33% Hct
Vitamin K dependent factors
Factors: II VII IX and X
Name 2 inherited coagulation factor disorders.
Hemophilia A
Hemophilia B
Name the 4 categories of coagulation instrument technologies.
visual
mechanical
magnetic
optical
What are the primary lymphoid organs?
Bone marrow, Thymus
Name the 4 major blood groups
A, B, AB, O
What are the factors involved in the extrinsic pathway?
III, VII, ionized Calcium
What is the major use of aPTT?
Monitor heparin therapy
What anticoagulant is used to preserve donated blood?
CPDA
What immunoglobulin is involved in the primary immune response? Secondary response?
IgM; IgG
D, C, c, E, e
What are the 3 coagulation pathways?
Intrinsic, Extrinsic, Common
3 conditions the D-Dimer test can aid in evaluation and diagnosis
DIC DVT PE
What are the 3 donor blood components?
RBCs, Platelets, plasma
Which immunoglobulin has the ability to cross the placenta
IgG
What is this patient's blood type?
anti-A = 0
anti-B = 0
anti-D = 0
A cells = 4+
B cells = 4+
Explain primary hemostasis (2 steps), which is the process of forming the temporary platelet plug.
platelet adhesion (platelets stick to damaged tissue)
and
platelet aggregation (platelets recruit more platelets which clump together to form plug)
A farmer was was pinned under his tractor. Fortunately, a friend was nearby and summoned help. In the E.R., his symptoms were pain, bleeding & signs of blood clots. What is a possible diagnosis & what test would you order?
DIC; D-Dimer, PT aPTT, fibrinogen, platelet count
What method of blood bank testing is considered the gold standard?
Tube testing
What are the 2 types of specific immunity & the cell involved in each?
humoral immunity---->B cells
cell-mediated immunity--->T cells
What is Hemolytic disease of the Newborn?
Mom's antibody attacks baby red cell antigens (ex - D)