NK T cells all have the same receptor. This is called?
Inverient
100
Happy holidays
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100
NK T cells can act as both T helper cells and Cytotoxic t cells. Describe what it means to be both (general idea)
Helper T cells>secrete Cytokines;;;;; cytotoxic t cells>Kill target cells
100
What kind of cell will try to kill a tumor cell?
NK cell
200
Nk Cell killing is stimulated by what?
IFN-a, IFN-B and IL-12
200
Fas-FasL mediated Lysis: Fas associated with what?
FADD? casues caspase cascade and apoptosis
200
First step in CTL killing :|
Conjugate formation of CTL and target cell (via MHC class 1)
200
Whats more efficient at delivering IL-2 to CTL, Sequential or Simultaneous? AND what does IL-2 do?
Simultaneous; Causes differentiation into CTL
200
SO peptide antigen= what kind of t cell, and what class MHC
helper t cell (CD4+) class 2 MHC, will help B2b cells (TD B cells) woooo look at me goo.
300
NK cell killing happens before CTL, SO when NK cells decrease, what kind of killing increases?
CTL increases (about day 5)
300
What are the two ways licencing can occur?
1) via CD40 and CD40L (helper T cell) OR through engagement with pathogens(TLRs)
300
Generation of CTL: sequential
CD4+ T cell help BEFORE dendritic and precursor of CTL engage
300
Tc1: Secretes? Methods of killing?
Secretes: IFN-y
Method of killing= FAS and Perforin
300
Tc2: Secretes? Method of killing? WHAT DOES IT LACK??
Secretes:IL-4 & IL-5
Method of Killing= Perfomin
(LACKS FAS)
400
What are the 3 signals for CTL generation?
1) Antigen recognized by class 1 MHC on a licensed APC
2) CD80/86 interaction between T cell and APC
3) IL-2 with receptor> Proliferation and differentiation
400
What signals NK cells to kill?
Missing Self model>>>absence or decrease of MHC class 1 will signal the NK TO KILL
400
What type of cell binds to carbs not peptide, also what kind of b cell recognizes Carbs?
NKT cell; B1B (is the important one)
400
Granzyme and perforin mediated lysis: what allows the release of Granzyme B into the cytoplasm of the target cell
Cylindrical pores created via perforin
400
NK cell killing produces what cytokine?
IFN-Y
500
Activating receptors for NK cell killing.
NKG2D binds to MIC-A and MIC-B, NCRs for Tumors
500
NK T cell depend on what method of killing?
Mostly FasL, but can also use granzymes/perforin
500
NK T Cell recognizes what molecule?
CD1d (glycolipid) CARBS NOT PROTEINS
500
Inhibitory to NK cells? (no killing)
Presence of MHC class I, KIR binds to HLA-B and C, and CD94-NKG2A binds to HLA-E.