Neurotransmitters
Primary inhibitory neurotransmitter in the CNS
GABA
Nicotine can bind to this ACh receptor and mimic ACh.
Nicotinic acetylcholinergic receptor
Nicotinic agonist
Nicotine
Toxin that prevents ACh release at the neuromuscular junction.
Botox
Excess glutamate activity leads to what process
Excitotoxicity
Primary excitatory neurotransmitter in the brain
Glutamate
Black widow spider venom increases the influx of which specific ion?
Ca2+
Drug that mimics neurotransmitter action
Agonists
Result of Botox at neuromuscular junction
Paralysis
Psilocybin affects which neuronal receptors?
Serotonin receptors
Neurotransmitter most involved in the autonomic nervous system (muscle contraction, learning & memory), that can be either excitatory or inhibitory
Acetylcholine
Curare blocks synaptic transmission at this neuronal receptor.
The nicotinic acetylcholinergic receptor.
Drug that blocks neurotransmitter action
Antagonist
What proteins are affected by botulinum toxin? (hint: they can no longer carry synaptic vesicles to the active zone)
SNARE proteins
Alcohol binds to which neuronal receptor?
GABAA
How do SSRI's affect the NTM, serotonin?
They reduce reuptake of serotonin by blocking transporter proteins.
Fast excitatory glutamate receptor with Na⁺ influx (hint: it is only ligand gated)
AMPA
Irreversible nicotinic antagonist that takes days to cleave away (paralyzes respiratory muscles by preventing ACh transmission).
Cobra Venom
Cocaine binds to which receptors in the brain?
Dopamine receptors
Epinephrine is typically released during which nervous system response?
The sympathetic nervous system response.
Alcohol, valium, and xanax all bind to which neuronal receptor?
GABAA
Glutamate receptor MOST critical for long term potentiation (LTP)
NMDA
Name a drug or toxin that affects serotonin receptors.
LSD, psilocybin
What happens if someone drinks alcohol while taking a benzodiazepine?
loss of consciousness, coma or death
NMDA antagonist used for Alzheimer’s disease, drug addiction, and PTSD?
Memantine