Sugars
Lipids
Nucleotides
Michaelis-Menten
Miscellaneous
100
Which of the names and Fischer representations of various monosaccharides match with the chair structure shown below?
B & I
100
What is the shorthand for oleic acid?
18:1c(Δ9)
100
Select all the appropriate descriptions that apply to uridine 5′-triphosphate.
It has a triphosphoryl group
It has a monophosphoryl group
It is a pyrimidine nucleotide
It is a purine nucleotide
It is a pyrimidine nucleoside
It is a purine nucleoside
It has a diphosphoryl group
triphosphoryl & pyrimidine
100
Consider the first-order conversion of reactant A to product B as shown below. If k1 is equal to 0.016 s−1 and k2 is equal to 0.004 s−1, then what is the equilibrium concentration of B assuming the reaction was started with an initial concentration of A of 1.0 M?
Not possible to determine with the information given
0.4 M
0.8 M
0.5 M
0.6 M
0.2 M
0.8 M
100
A nonapeptide that contains Ser, Pro, Ala, Arg, Lys, Tyr, Gly, Thr, and Phe was incubated with Sanger’s reagent, and FDNB-Ala was detected. A second sample of the nonapeptide was incubated with carboxypeptidase A, and no products were detected. Digestion of another sample of the nonapeptide with chymotrypsin yielded a tripeptide and a hexapeptide. Digestion of yet another sample of the nonapeptide with trypsin yielded a pentapeptide and a tetrapeptide. Finally, partial hydrolysis of the nonapeptide yielded the following di- and tripeptides, the amino acid compositions of which were as follows:
R, F, P T, S, G P, Y, F A, S Y, G, K
Given the above information, what is the sequence of the nonapeptide? Enter your answer using the one-letter code.
ASTGKYFPR
200
The molecule below is a naturally occurring disaccharide made up of D-monosaccharides linked via a glycosidic bond. What is the designation of the glycosidic bond? Hint: One of the monosaccharides has been “flipped”.
β(1→4)
200
What is the general name for the lipid shown below?
glycerophospholipid
200
At physiological pH, guanine has
5 carbons, 5 hydrogens, 1 oxygen, and 5 nitrogens
5 carbons, 5 hydrogens, 1 oxygen, and 4 nitrogens
None of the other answers is correct
6 carbons, 7 hydrogens, 1 oxygen, and 5 nitrogens
5 carbons, 7 hydrogens, 1 oxygen, and 4 nitrogens
5 carbons, 5 hydrogens, 1 oxygen, and 5 nitrogens
200
Describe what uncompetitive inhibition is and what the double-reciprocal plot looks like.
Uncompetitive inhibition is when the inhibitor binds to the ES complex. The graph should have 2 parallel lines.
200
What would be the approximate net charge of the peptide shown below at pH = 6.5? To facilitate answering this question, assume that the N-terminal aminium group has a pKa of 8, the C-terminal carboxyl group has a pKa of 3.5, and that the ionizable side chains have pKas as follows: Asp = 4.0, Glu = 4.0, His = 6, Cys = 8.4, Tyr = 10, Lys = 10, and Arg = 12.5. Also, assume that if the pH is at least two units above or below the pKa of a particular group, then that group is completely unprotonated or protonated, as the case may be. Report your answer to the nearest hundredth.
0.21
300
Which of the names and Fischer representations of various monosaccharides match with the chair structure shown below?
C & II
300
Which of the following is an appropriate name for the lipid shown below?
Sphingomyelin
Phosphatidylcholine
Phosphatidylglycerol
Phosphatidylethanolaminium ion
Triacylglycerol
Phosphatidylserine
Sphingosine
Phosphatidylinositol
Phosphatidylethanolaminium ion
300
Deoxythymidylate refers to which of the following?
Deoxythymidine 5´-monophosphate (dTMP)
Deoxythymidine 5´-triphosphate (dTTP)
All of the choices are correct
Deoxythymidine 5´-diphosphate (dTDP)
Deoxythymidine 5´-monophosphate (dTMP)
300
Which of the following expressions correctly shows the Lineweaver-Burke (or double-reciprocal) equation in the case of uncompetitive inhibition? Select all that apply.
None of the other choices is correct
choice 2
300
Consider the below kinetic mechanism, which is shown in the shorthand notation suggested by W. W. Cleland. Which of the following statements concerning this kinetic mechanism is or are correct? Select all that apply.
The rate constant for the step EB + A → EAB has units of reciprocal concentration and reciprocal time.
The mechanism is best described as Ordered Bi Uni
The rate constant for the step E + P → EP (i.e., the first step of the back reaction) has units of reciprocal time.
The mechanism is best described as Ordered Uni Bi
The rate constant for the step EP → E + P has units of reciprocal time.
The rate constant for the step EA + B → EAB has units of reciprocal time.
The rate constant for the step EB + A → EAB has units of reciprocal concentration and reciprocal time.
The rate constant for the step EP → E + P has units of reciprocal time.
400
What is the name of the disaccharide shown below?
maltose
none of the other choices is correct
lactose
sucrose
maltose
400
What are the relative (D or L) and absolute (R or S) configurations about the chiral carbon in the alien lipid shown below? Consider the top-most carbon of the glycerol backbone to be C1, the middle (chiral) carbon of the glycerol backbone to be C2, and the bottom-most carbon of the glycerol backbone to be C3.
L and R
D and R
L and S
D and S
D & S
400
You analyze both strands of a DNA double helix and determine that the proportion of A’s is 0.26 and the proportion of G’s is 0.24. Which of the following is true about the proportions of T’s and C’s? Select all that apply.
The proportion of T’s = 0.26 and the proportion of C’s = 0.24
The sum of the proportion of the T’s and the proportion of the C’s = 0.50
none of the other choices is correct
The sum of the proportion of the A’s and the proportion of the G’s = 0.50
The proportion of T’s = 0.24 and the proportion of C’s = 0.26
The proportion of T’s = 0.26 and the proportion of C’s = 0.24
The sum of the proportion of the T’s and the proportion of the C’s = 0.50
400
Which of the following expressions correctly shows the relationship between the true x-intercept and the apparent (or observed) x-intercept in the Lineweaver-Burke (or double-reciprocal) approach to enzyme kinetics in the case of an uncompetitive inhibitor? Select all that apply.
None of the other choices is correct
Last choice
400
Imagine that inside a cell the concentration of ATP = 3 mM, the concentration of ADP = 0.7 mM, and the concentration of inorganic phosphate = 3.9 mM. Furthermore, imagine that the pH inside the cell is 7.3. Given that G°' for ATP hydrolysis is -7.3 kcal/mol, what is the G for ATP hydrolysis inside the above-described cell, which is at 37 °C? Report your answer in terms of kcal/mol to the nearest tenths. Hint: you might wish to consult the handout Equations, Math Concepts, and Conversions posted on Canvas. Also, recall that the equation for ATP hydrolysis is as follows:
ATP + H2O ⇌ ADP + Pi + H+
-12
500
What is the monosaccharide shown below?
α-D-idofuranose
500
An analysis of a lipid indicates a 1:1:1:1 mol ratio of the following: 18:0 fatty acid, inorganic phosphate, ethanolamine, and an 18-carbon amino alcohol. This lipid most likely is:
Sphingomyelin
Ganglioside
Triacylglycerol
Phosphatidylethanolamine
Phosphatidylcholine
Cholesterol
Sphingomyelin
500
Describe the major contributions of each of these people:
Griffith
Miller-Urey
Mesehlson-Stahl
Hershey-Chase
Griffith: transformation
Miller-Urey: original building blocks of life can be created in early Earth
Mesehlson-Stahl: semiconservative replication
Hershey-Chase: DNA is the hereditary material (blenders)
500
The molecule below is a naturally occurring disaccharide made up of D-monosaccharides linked via a glycosidic bond. What is the designation of the glycosidic bond? Hint: One of the monosaccharides may have been “flipped”.
α(1→4)
α(1→5)
α(1→1)α
β(1→5)
β(1→2)
α(1→5)β
β(1→4)
α(1→2)
α(1→2)β
β(1→1)α
α(1→2)β
500
The following question is offered in anticipation of our chapters on metabolism: Assuming that the average weight of an adult is 157 lbs, how many molecules of oxygen arrive each second at a mitochondrion of an average active person? Assume that oxygen consumption is 42 mL per minute per kilogram of body weight, adults have about 1x10^12 cells, and there are 840 mitochondria per cell. Assume that one pound equals 0.454 kg, and that oxygen gas occupies 22.4 L per mol. Report your answer to the nearest ones.
1,596,861