DLTs
Precautions/AEs
Targeted Therapy
Chemoprevention
Potpourri
100
Doxorubicin
What is cardiomyopathy?
100
High dose Ara-C
What is conjuctivitis, cerebellar toxicity, hand-foot syndrome?
100
Indication & Adverse Events Bevacizumab
What are solid tumors (anti-VEGF)? What are HTN, thrombosis, hemorrhage, proteinuria?
100
Filgrastim (G-CSF)
What is reduce duration of neutropenia by stimulating hematopoietic progenitor cells? Dose: 5 mcg/kg/day (round to 300/480 mcg)
100
Measures to prevent nausea and vomiting from highly emetogenic chemotherapy
What are ondansetron/palonsetron, aprepitant, dexamethasone, +/- lorazepam?
200
Cisplatin
What is nephrotoxicity, ototoxicity, nausea/vomiting?
200
Ifosfamide
What is hemorraghic cystitis, neurotoxicity, nausea/vomiting, myelosuppression?
200
Indication & Adverse Events Rituximab
What is B-cell malignancies (anti-CD20)? What are infusion-related reactions, PRES, tumor lysis syndrome, possible hepatitis B reactivation?
200
Mesna
What is binds acrolein to prevent hemorrhagic cystitis with ifosfamide and cyclophosphamide? Dose: 60-100%
200
Indications for use of Megace
What are breast cancer, endometrial cancer, hot flashes, and cancer-related cachexia?
300
Irinotecan
What is diarrhea?
300
Methotrexate
What is urine alkalinization (pH > 7), leucovorin rescue?
300
Indication & Adverse Effects Gemtuzumab ozogamycin
What is AML (anti-CD33)? What are myelosuppression, infusion-related reactions, hepatotoxicity/VOD?
300
Leucovorin
What is rescues toxic effects of methotrexate? Continue until level < 0.05 micromol/L
300
Side effects associated with high-dose IL-2
What are fever, flushing, hypotension, rash, neutropenia, infection, edema, depression, and gastritis?
400
Cyclophosphamide
What is hemorrhagic cystitis, myocarditis?
400
Docetaxel
What is peripheral edema, hypersensitivity, myelosuppression? Follow-up question: How do we prevent edema?
400
Indication & Adverse Events Imatinib
What is CML (tyrosine kinase inhibitor)? What are fluid retention (periorbital edema), hepatoxicity, myelosuppression, rash, nausea/vomiting?
400
Dexrazoxane
What is can be used with doxorubicin to decrease the risk of anthracycline-induced cardiomyopathy? Dose = 10x doxorubicin dose
400
Measures to prevents tumor lysis syndrome
What are hydration, allopurinol, and rasburicase?
500
Vincristine
What is peripheral neuropathies? Follow up question: What is the max weekly dose of vincristine?
500
Thalidomide/Lenalidomide
What is myelosuppression, diarrhea, rash, fatigue, birth defects, VTE?
500
Indication & Adverse Events Trastuzumab
What is breast cancer (anti-HER2)? What are cardiomyopathy, infusion-related reactions?
500
Amifostine
What is used to prevent nephrotoxicity associated with cisplatin? Dose = 910 mg/m2 IV
500
Use and side effects associated with ATRA
What is APL? What is retinoic acid syndrome (unexplained fever, elevated WBC, respiratory distress, pleural/pericardial effusions, ARF)?
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