Dosing and Adm
How is Cleviprex administered
What is via a dedicated Central or Peripheral Line?
Metabolism via ________ and _________
What are plasma and tissue esterases?
MOA of Cleviprex?
What is Cleviprex dilates arteries via Calcium channel blockade and reduces cardiac afterload without affecting preload?
In Velocity, oral antihypertensive therapy was initiated ___ hour prior to the anticipated cessation of Cleviprex infusion.
What is 1 hour?
Concentration of Cleviprex
What is .5mg/mL
The Year the AHA/ASA AIS Guidelines came out adding Cleviprex
What is cuff monitoring?
What is negative and exacerbate
Metabolism of Cleviprex
What is hydrolysis of the ester linkage, primarily by esterase's in the blood and extravascular tissues?
What is 4-6 mg/hr?
Onset of Action of Cleviprex
What is 2-4 min?
Time Range of infusion of Cleviprex in Velocity
What is 18-96 hours?
Possible consequences of rapid upward titration of Cleviprex
What is hypotension and reflex tachycardia?
(If either occurs decrease the dose)
Calorie and lipid content of Cleviprex
What is 2.0kcal and .2g of lipid per mL?
Dosing is _______ and independent of ______ and r______ function
What is dosing is non-weight based and independent of renal and kidney function?
Half-life of Cleviprex with full blood pressure recovery
What is 1 min half-life with full BP recovery 5-15 min after infusion is stopped in most patient?
What is the Emergency Department and the ICU?
Beta blocker withdrawal
What is only after a gradual reduction in Cleviprex dose?
Lipid Intake Restrictions
What is may be necessary fro patients with significant disorders of lipid metabolism?
What is discontinue Clevirpex or down-titrate as oral therapy takes effect?
Treatment option for Cleviprex under AIS guidelines:
for acute repercussion therapy except that BP is >185/110 mg/ Hg or for AISU
for AISU patient who has either SBP >180-230 or DBP >105-120 mm Hg
What is Clevidipine 1-2mg/h IV, titrate by doubling dose every 2-5 min until desired BP is achieved.
Primary and Secondary Outcomes in Eclipse
What is Safety outcome (incidence of death, MI, stroke or renal dysfunction at 30 days) and secondarily adequacy and precision of BP control?
Cleviprex does not reduce cardiac filing pressure (______) confirming lack of effects on the _______.
What is pre-load and venous capacitance vessels?
Mean duration of Cleviprex exposure in Velocity?
What is 21 hours?