Phases
Name the Phase where the solid oral tablet dissolves into a liquid form
Pharmaceutic Phase
What term represents the way a drug acts on the body?
Pharmacodynamics
The time it takes for a medication to reach its highest effective concentration
Peak
What is the name of the agency that regulates drug, quality, safety and labeling?
FDA
A patient has severe dehydration. Which is the best route for fluid administration?
Intravenous route
Name the 4 factors addressed in the pharmacodynamic phase
1). Absorption
2). Distribution
3). Metabolism
4). Excretion
What term represents the way the body acts on a drug?
Pharmacokinetics
Time during which medication is present in concentration great enough to produce a response
Duration
What is a controlled drug?
A drug that has a high potential for abuse
A patient with pneumonia tells the nurse he is allergic to PCN. What is the most appropriate response by the nurse?
What type of reaction did you have when you took PCN
When a drug is absorbed from the digestive tract (stomach and intestine) it enters into the hepatic portal circulation where what effect happens
First-Pass effect where drug is metabolized and concentration is reduced before it reaches systemic circulation
What does Pharmacokinetics quantitatively describe?
Drug disposition: Absorption, Distribution, Metabolism, and Elimination
Time it takes after a medication is administered for it to produce a response
Onset
How does Orphan Drug Act of 1983 encourage the development of drugs to treat patients with rare diseases?
Government provides Tax incentives and exclusive license to market drug
Your geriatric patient took Ambien to help her sleep, however, she felt restless all night and didn't sleep at all. The nurse recognizes that the patient has experienced which type of reaction?
Idiosyncratic reaction
Receptor mediated drug actions occur in what phase
Pharmokinetic phase
What drug disposition represents the way a drug leaves the body?
Elimination
Minimum blood serum concentration of medication reached just before the next scheduled dose
Trough
Name the 5 rights every patient has regarding prescription medications
1). Right drug
2). Right dose
3). Right route
4). Right time of administration
5). Right patient
While caring for a patient with liver cirrhosis, the nurse knows that abnormalities in which phase of pharmacokinetics may occur?
Metabolism
Name the type of drug that blocks cellular activity at the receptor site
Antagonist
What drug disposition is altered by differing gastric pH?
Absorption
Immediate,life-threatening reaction to the release of bioactive substances from mast cells and basophils mediated by IgE
What Phase of clinical trials is a small number of volunteers tests to confirm what pharmacologist thought from animal testing for the investigational new drug?
Phase 1
A drug delivers 650 mg has a half-life of 3 hours. How many milligrams of drug will remain in the body after 1 half-life?
325 mg