Micro/Hypo
Macrocytic
Sickle Cell & Friends
Thalassemia
Morphology Surprise
100

This is the most common microcytic/hypochromic anemia.

What is Iron Deficiency Anemia?

100

These types of anemias are cause by deficiencies in Folic acid and B12.

What are megaloblastic anemias?

100

This test is a confirmatory test for hemoglobinopathies.

What is hemoglobin electrophoresis?

100

Disorders involving impaired production of one or both of a pair of polypeptide chains in the hemoglobin molecule.

What is thalassemia?

100

DD: This is a bone marrow smear.  Name the condition.  (Image #1)

What is aplastic anemia?

200

Iron Deficiency Anemia is caused by these two mechanisms.

What is insufficient intake of dietary iron or in

adequate iron adsorption?

200

DD: Nuclear development which lags behind cytoplasmic development results in this cell type.

What is macrocytic?

200

DD: These are two striking features of the Hgb C hemoglobinopathy.

What are high numbers of target cells and Hgb C crystals?

200

Homozygous beta-thalassemia or beta-thalassemia major is also known as:

What is Cooley's anemia?

200

DD: This is a peripheral blood smear.  Name the disease.  (Image #2)

What is Hgb C disease?

300

DD: Precipitated iron granules around the nucleus of nucleated RBCs is characteristic of this type of anemia, often caused by radiation exposure or lead poisoning.

What is Sideroblastic anemia?

300

Defective production of intrinsic factor is the most common cause of this type of anemia.

What is B12 deficiency or pernicious anemia?

300

This test used to detect the presence of Hgb S cannot detect the difference between sickle cell disease and sickle cell trait.

What is Sickledex or Sicklequik test?

300

DD: Alpha thalassemia minor is usually characterized by this disease presentation.

What is asymptomatic or mild microcytic anemia?

300

What type of anemia is associated with this peripheral blood smear? (Image #3)

What is folate/B12 deficiency?

400

A patient is suspected of having an Iron Deficiency Anemia.  An iron panel is ordered: Serum iron, ferritin, transferrin, TIBC.  These are the expected results.

What is Serum iron=decreased/normal, ferritin=decreased, transferrin=increased, TIBC=increased.

400

Folic acid deficiency is usually caused by this.

What is dietary insufficiency?

400

The type of hemoglobin molecule is less soluble than normal hemoglobin in the tense (deoxygenated) state.

What is Hgb S?

400

Type of thalassemia associated with fetal demise, no normal adult hemoglobin production, and the complete absence of alpha chains.

What is Alpha thalassemia major or hydrops fetalis?

400

Interpret these Hgb electrophoresis results. (Image #4)

What is sickle cell trait?

500

Disorders involving impaired production of one or both of a pair of polypeptide chains in the hemoglobin molecule.

What is thalassemia?

500

A test once used to determine Vitamin B12 deficiency that involves a 24-hour urine specimen collection following a radioactive-labeled Vitamin B12 taken orally.

What is Schilling test?

500

A point mutation in the beta-chain where glutamic acid is replaced by lysine at the number 6 position produces this hemoglobinopathy.

What is Hgb C?

500

Name of the disease cause by deletions of 3 alpha genes.

What is Hgb H disease?

500

What type of anemia is associated with this peripheral blood smear? (Image #5)

What is Hgb SC disease?

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