Coag. factor to group
Match each coagulation factor to the correct group based on its properties.
factor I
thrombin sensitive
A patient with classic von Willebrand disease will present with which of the following test results?
Result APTT Platelet screen Ristocetin A NORM NORM ABN
B ABN ABN ABN
C ABN NORM NORM
D NORM ABN NORM
RESULT B
Normal platelets have a circulating life-span of approximately
10 days
The two factors that differentiate liver disease from vitamin K deficiency are ____________and_________
V and VIII
Heparin induced thrombocytopenia (HIT) is an immune mediated complication associated with heparin therapy. Antibodies are produced against:
-platelet factor 4 (PF4)
-anti-thrombin (AT)
-anti-cardiolipin antibodies (ACLA)
-B2GP1
platelet factor 4 (PF4)
factor II
vitamin K dependent
Which of the following platelet responses is most likely associated with hemophilia A?
-normal platelet aggregation
-defective ADP release, normal response to ADP
-marked decreased aggregation to epinepherine, ADP, and collagen
-decreased amount of ADP in platelets
normal platelet aggregation
The largest cell seen in the bone marrow is the
megakaryocyte
Which of the following statements is true about acute idiopathic thrombocytopenic purpura (ITP)?
-Spontaneous remission usually occurs within several weeks.
-It is found primarily in adults.
-Women are more commonly affected.
-Peripheral destruction of platelets is decreased.
Spontaneous remission usually occurs within several weeks.
In the Clause fibrinogen method, the time to clot formation in plasma is measured after the addition of:
thrombin
factor XI
contact group
The following laboratory results were obtained from a male with a long history of abnormal bleeding:
Test Patient result
Prothrombin time normal
APTT markedly prolonged
Factor VIII markedly decreased
Factor VIII related antigen normal
Platelet count normal
Bleeding time normal
Which of the following disorders does the man most likely have?
classic hemophilia
vWF antigen can be found in which of the following?
megakaryoblast
Which of the following is characteristic of platelet disorders?
-mucous membrane hemorrhages
-deep muscle hemorrhages
-retroperitoneal hemorrhages
-severely prolonged clotting times
mucous membrane hemorrhages
Which test should be used to monitor low molecular weight heparin therapy?
chromogenic anti factor V assay
kalikrein
contact group
A patient presents with bleeding 48 hours after a tooth extraction. The following laboratory results are obtained:
Test Patient results Reference
PT 11.5 seconds 10 - 13
APTT 32.5 seconds 23 - 35 Fibrinogen 345 mg/dL 200-400 Platelets 324 x 103/μL 150 - 450
factor XIII
Most coagulation factors are synthesized in the
liver
In the APTT test, the patient's plasma is mixed with
phospholipid and calclium
Acute disseminated intravascular coagulation is characterized by:
hypofibrinogenemia
or reduced level of circulating fibrinogen
factor V
thrombin sensitive
A patient develops severe unexpected bleeding following four transfusions. The following test results were obtained:
Test Patient result
PT prolonged
APTT Prolonged
Platelets 50 x 103/μL
Fibrinogen 30 mg/dL
D-dimer increased
Given these results, which of the following blood products should be recommended to the physician for this patient?
cryoprecipitate
Which coagulation factor is only used in the extrinsic pathway?
VII
The ISI in the INR represents the reagents
sensitivity
Aliquots of plasma with a prolonged PT and prolonged APTT are mixed using various ratios of patient plasma and normal plasma. All samples are incubated at 37∘C and tested at 10 minutes, 30 minutes, and 60 minutes. The PT and APTT results on all of the mixtures are corrected. These results would indicate the presence of:
a factor deficiency