C
Also referred to as Factor IV, _____ is an inorganic ion necessary for all stages of coagulation
Calcium
___ is the process during hemostasis that reinforces the platelet plug that can be initiate by either the intrinsic or extrinsic pathway
The coagulation cascade
In the second phase of coag, the conversion of prothrombin into the active enzyme thrombin is referred to as the ___ pathway
Common
Fibrinolysis is the process of ___ following hemostasis and clot retraction
Breaking down a clot
Large amounts of ___ are incorporated into a forming clot where it is inactive until appropriate signals reach it to break down the clot
Plasminogen
In the extrinsic pathway, tissue cell trauma exposes blood to ___ to start the coag cascade
Tissue Factor or Factor III
In the first phase of coagulation, Factor X is activated by Factor ___ complex from the extrinsic pathway
VII and III (Tissue Factor)
In the first phase of coag, once Factor X has been activated it complexes with calcium ions and Factor V to form the complex called ____
Prothrombinase
The enzyme that breaks down fibrin is ___
Plasmin
What is the main role of thrombin in the process of blood clotting?
Converting Fibrinogen to fibrin
In the third phase of coag, in the presence of calcium, thrombin activates the cross linking enzyme ___ that binds fibrin strands together to make fibrin mesh
XIII
In the extrinsic pathway, tissue factor activates Factor ___
VII
Fibrinogen is a (soluble or insoluble) clotting factor that is converted into fibrin
Soluble
The process of ___ begins within two days and continues over several days to dissolve a clot
Fibrinolysis
Which substance is released by body cells to prevent blood from clotting inside blood vessels
Heparin
In the second phase of coag, prothrombin activator catalyzes the conversion of prothrombin into the active enzyme ___
Thrombin or IIa
In the first phase of coagulation, Factor X is activated by Factor ___ complex from the intrinsic pathway
IX and VIII
In the third phase of coag, ___ molecules polymerize to form long strands to glue platelets together
Plasmin is activated from inactive ___ by tissue plasminogen activator and urokinase
Plasminogen
What is the main symptom of someone with hemophilia?
Prolonged bleeding
In the intrinsic pathway of coag, Factor ___ is activated by blood circulating over injured internal surfaces of blood vessels which are negatively charged
The first phase of coagulation involves either the cascade of the intrinsic or extrinsic pathway to activate the common intermediate Factor ___
X
In the intrinsic pathway of coag, ___, the first plasma protein to be activated has the ability to weakly activate plasmin and initiates inflammation
XII
Platelets
Protein S and Thrombin