Incontinence Say What
These three primary factors contribute to urinary incontinence in women
What are pregnancy, childbirth and genetics?
This part of a clinical article tells you about the study design, patient population, statistical techniques
What is Method?
A measure of the relative risk of an event in one group compared to another
What is Risk Ratio?
Primary objective of the Cochrane Review on single-incision slings for urinary incontinence
What is to evaluate the effectiveness and safety of single-incision sling operations for urinary incontinence in women compared to other surgical treatments?
What are the lack of studies comparing them to conservative treatments, insufficient data on long-term outcomes and small sample sizes in existing studies?
Painful sexual intercourse
What is dyspareunia?
This study design is considered the "gold standard" of clinical studies
What is Randomized Controlled Trial (RCT)?
A range of values within which the true effect size is likely to lie
What is Confidence Interval?
The number of clinical studies and women included in this Cochrane Review
What is 62 studies and over 8,000 women?
This single-incision sling was sub-grouped on the Cochrane Review due to its concerns on safety and efficacy and removed from the market in 2013
What is TVT-Secur?
New onset of urgency symptoms after a surgical procedure
What is De Novo Urgency?
A statistical technique that combines the results of multiple studies to provide an overall estimate of effect
What is Meta-Analysis?
A measure of the difference in means between groups, standardized to the standard deviation
What is the Standardized Mean Difference?
Two methods used to assess the risk of bias in the included studies in this Cochrane Review
What are random sequence generation and blinding?
Assessing risk of bias is crucial because it helps determine the reliability and validity of the studies included, and consequently, the overall conclusions of the review.
These factors contributed most to the heterogeneity in study populations in comparing different types of mid-urethral slings in the Cochrane Review
What are differences in surgical technique & surgeon experience?
The inability to completely empty the bladder, often used as a clinical outcome measure in studies on mid-urethral slings
What is urinary retention?
A type of systematic review, conducted by a global network of researchers, that synthesizes evidence from multiple studies to answer a specific clinical question, aiming to provide reliable and unbiased information for healthcare decision-making
What is the Cochrane Review?
A systematic approach to assessing the certainty of evidence in systematic reviews by considering factors such as risk of bias, inconsistency, indirectness, imprecision, and publication bias. It helps healthcare providers and patients make informed decisions.
What is the GRADE approach?
The rate mesh exposure, extrusion, or erosion differ between single-incision slings and retropubic slings in the Cochrane Review
What is no clear difference between single-incision slings and retropubic slings?
The 95% CIs are wide and inconsistent.
This statistical concern is highlighted in the Cochrane Review as a limiting factor in validating the comparisons (hint - type of clinical trial)
What is the lack of head-to-head randomized controlled trials?
A discoordination between the contraction of the bladder muscle and the relaxation of the urethral sphincter
What is dyssynergia?
A measure of the variability or inconsistency among studies in a meta-analysis.
What is Heterogeneity?
The acronym PICO stands for
Patient/Population, Intervention, Comparison & Outcome
The overall conclusions of the Cochrane review regarding the effectiveness and safety of single-incision slings for urinary incontinence
What is single-incision slings have comparable efficacy and safety to other sling types?
This could be why the Cochrane Review may not fully address a surgeon's concerns about single-incision slings
What is a lack of detailed subgroup analyses comparing different single-incision sling devices?