Famous Patients
Models & Theories
Explicit Memory
Implicit Memory
Neuroanatomy
100

This patient suffered severe anterograde amnesia after a bilateral medial temporal lobe resection to treat epilepsy.

Patient HM

100

"Neurons that fire together, wire together" is the simple summary of this rule.

Hebb's Rule

100

This is the distinction between memory for personal events and memory for facts.

Episodic vs. semantic memory.

100

Procedural memory for skills and habits relies on this brain structure, not the hippocampus.

Striatum

100

According to the memory taxonomy, this structure is critical for learning emotional responses.

Amygdala

200

This patient lost his ability to recall any personal episodic memories but retained his semantic knowledge.

Patient KC

200

This model classifies recognition memory responses as Hits, Misses, False Alarms, or Correct Rejections.

Signal detection theory.

200

In a free recall task, this is the term for the superior recall of items from the end of the list.

Recency effect

200

This is the process of associating an involuntary response, like salivating, with a previously neutral stimulus, like a bell.

Classical Conditioning

200

A patient with a lesion here might show fear conditioning but be unable to declaratively state what they are afraid of.

Hippocampus

300

Patient H.M. proved he could still form nondeclarative memories by improving his performance on this motor skill task.

Mirror Drawing Task

300

This "standard model" proposes that memories become independent of the hippocampus and are stored in the neocortex over time.

Systems Consolidation Theory
300

The sense of familiarity for an individual or object when you see it out of its original context is sometimes referred to as...

the "butcher on the bus" phenomenon

300

This task demonstrates implicit motor learning, as people get faster at repeated sequences without conscious awareness.

Serial Reaction Time Task (SRTT)

300

Taxi drivers who successfully acquired the map of this complex city showed an increase in hippocampal volume.

City of London

400

This patient with bilateral amygdala calcification has a selective deficit in recognizing fearful facial expressions.

Patient SM

400

This model splits recognition into two components: Familiarity (quantitative, fast) and Recollection (qualitative, slow)

dual process model

400

This is the tendency for people to have an increased number of autobiographical memories from their adolescence and early adulthood.

The Reminiscence Bump

400

Motor sequence learning is notably impaired in this disease, which affects dopaminergic circuits in the basal ganglia.

Parkinson's Disease

400

While the amygdala handles external fear cues, this brain region is linked to interoceptive (internal) events and the subjective experience of fear.

Insula

500

In the Bechara et al. (1995) study, this patient group had no fear conditioning (skin conductance) but normal declarative recollection.

Amygdala lesion group.

500

Karl Lashley's theory that the proportion of brain damage, not its specific location, determines the degree of memory impairment.

Law of Mass Action

500

fMRI studies show that activation in this brain region, part of the anterior temporal network, varies as a function of familiarity strength.

Perirhinal cortex

500

This feedback signal—encoded by dopaminergic neurons—represents the difference between an expected and actual reinforcement outcome.

Reward Prediction Error

500

These are cells in the hippocampus that fire to an animal's specific location and cells in the entorhinal cortex that fire in a hexagonal pattern.

Grid cells

600

Patient S.M. experiences fear and panic when subjected to this interoceptive (internal) threat, but not from exteroceptive (external) threats like scary movies.

Inhaling 35% CO2

600

This MTL model proposes a "Posterior Medial" network for context, and an "Anterior Temporal" network for salient items

the PMAT framework

600

According to the PMAT model, this brain region is responsible for binding "Items in Context."

The Hippocampus
600

This is the process where a conditioned response is reduced by repeatedly presenting the conditioned stimulus (CS) without the unconditioned stimulus (US).

Extinction learning

600

During motor sequence learning, fMRI shows activation shifts from the ____ to the ____ part of the Putamen.

Dorsal (associative); Ventral (sensorimotor)

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