Founder of the Pennsylvania colony who preached acceptance of all people, including Native Americans (An artistic version of this man can be seen on Quaker Oats products).
William Penn
This illness was the deadliest of the Columbian Exchange and wiped out a large percentage of the Native American population in the New World.
Smallpox
This Middle Colony was originally controlled by the Dutch and was known as "New Amsterdam" before being controlled by the English and hosting a diverse population.
New York
Due to extreme hunger, the people of Jamestown partook in this taboo practice involving dead bodies in order to survive.
Cannibalism
This nickname is often associated with the settlers of Plymouth, although they originally referred to themselves as Separatists.
Pilgrims
This Norse explorer is believed to be the first European to set foot in continental America, roughly 500 years prior to Christopher Columbus.
Leif Erikson
This animal, which came from the Old World, revolutionized Native American culture, making them more dependent on hunting.
Horse
This Southern colony founded by James Oglethorpe that was built primarily as a buffer zone against Spanish founded Florida.
Georgia
This cash crop was the most profitable in all of Jamestown, and much of England was addicted to it in just a few decades.
Tobacco
This document served as the law of the land in Plymouth and established majority rule (it was named after the English ship that landed on Plymouth Rock).
Mayflower Compact
This man befriended Benjamin Franklin despite the fact that Franklin was a secularist and he was an Evangelical preacher in the midst of the Great Awakening.
George Whitefield
This food item that came from the Old World is important in helping make the beverage that makes many people wake up in the morning due to the presence of caffeine.
Coffee Beans
This Southern colony relied on Barbados residents to migrate to its settlement of Charles Town and on the plantation system to produce large amounts of rice and indigo for profit.
South Carolina
This man, who served as governor of Jamestown, was quoted as saying, "he that will not work shall not eat," and was part of a legend involving the 12-year-old Native American princess Pocahontas.
John Smith
This trade good was highly profitable for the settlers of Plymouth and important for building homes.
Lumber
Puritan woman who challenged male religious authority and was banished from the Massachusetts Bay Colony as a result.
Anne Hutchinson
This New World food item that made its way to the Old World is botanically a fruit but is considered a culinary vegetable.
Tomato
This Chesapeake colony created the Toleration Act that guaranteed tolerance and support for all Christians and, ironically, vitriol for all non-Christians.
Maryland
The Jamestown colony was founded just north of this separate English settlement, which mysteriously vanished, its fate still unknown more than 400 years later.
Roanoke Colony
This religion, which the settlers of Plymouth rejected, led them to fear persecution, which motivated their journey to America in the first place.
Church of England
This Portuguese explorer was the first to round Africa to reach India, something that Christopher Columbus had originally intended.
Vasco Da Gama
This crop, grown by many Native American tribes, was also referred to as maize before making its way to the Old World.
Corn
New England colony founded by clergyman Roger Williams that promoted religious freedom.
Rhode Island
This legislative body was formed in Jamestown to make decisions, though it largely followed England's lead on its laws.
House of Burgess
Native American man who helped the settlers of Plymouth how to grow crops, fish, and hunt.
Squanto