what's your bet?
Things in the Standard American Diet (SAD diet) that increases risk of CRC (aka why incidence of CRC in 20-30yo is rising). Name at least 3.
- diet high in red meat, processed meat
- diet low in fruit, vegetables, fiber, and dairy
Three pathogenesis mechanisms of CRC
What is chromosomal instability, microsatellite instability, and serrated neoplasia?
Age that all-comers in the US start screening for CRC?
What is age 45?
Hereditary pattern in Lynch syndrome
What is autosomal dominant?
Name of syndrome with multiple juvenile polyps found in the colon
What is Juvenile Polyposis syndrome?
Ethnicity with higher prevalence CRC
What is African-American?
Most common culprit in CRC (mechanism)
what is chromosomal instability
Frequency of FIT-DNA test to screen for colon cancer
What is every 1 to 3 years?
Most common cancer in Lynch syndrome (after CRC)
What is endometrial cancer?
What is Peutz-Jeghers Syndrome?
percentage of eligible Americans that have been screened for CRC (average risk)
What is approx 60%?
Through which mechanism do interval colon cancers (cancer that develops after negative colonoscopy and before next recommended screening) develop?
What is serrated neoplasia? (hypermethylation of tumor suppressor gens and development of serrated polyps and cancer)
ACG recommendations on how to take colonoscopy prep to increase detection rate
Half prep evening before, half prep day of scope starting 4 to 5 years before
Surgeries that should be offered to women with Lynch syndrome mutations
What is total hysterectomy and bilateral salpingo-oophorectomy?
What is PTEN Hamartoma Syndrome?
Serrated polyps are usually found in the...
What is the proximal colon?
Age that pts with IBD should start screening for CRC
What is eight years after diagnosis?
Name of clinical criteria with bad sensitivity but good specificity to diagnose Lynch syndrome
What is Amsterdam criteria?
Hereditary pattern in MutYH-Associated Polyposis
What is autosomal recessive?
Which type of GU surgeries with anastomoses increases risks of CRC
What is ureterocolic anastomoses after extensive bladder surgeries?
Most commonly mutated gene in the chromosomal instability pathway
What is the APC (adenomatous polyposis coli) gene?
Age that patients with familial adenomatous polyps should start CRC Screening
Age 10 to 12 years
Genetic basis for Serrated polyposis syndrome