Besremi PI
The black box warning for Besremi states:
Risk for serious disorders: may cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Monitor closely and withdraw therapy with persistently severe or worsening signs or symptoms of the above disorders.
This percent of patients required no transfusions (during the 24 week treatment period) on Ojjaara?
35%
According to the PharmaEssentia website, Besremi is the only FDA-approved treatment indicated for polycythemia vera (PV) that
Targets the source of the disease
Ojjaara is available in what doses?
100, 150 and 200mg tablets
Zero
How is Besremi supplied?
500mcg/mL solution in a single dose pre-filled syringe
Comparable rates of SVR greater than or equal to 35% were observed with Ojjaara and which agent?
Ruxolitinib
How many patients achieved Complete Hematologic Response (CHR) on Besremi?
6 out of 10
In the MOMENTUM Trial what percentage of patients discontinued Ojjaara permanently due to an AE?
19%
In Besremi clinical trials, how many cases of AML and MF were observed on the 7.5 years of safety analysis?
Zero AML
1 MF
What were the most common AE's reported with Besremi in greater than 40% of patients?
Influenza-like illness, arthralgia, fatigue, pruritus, nasopharyngitis, and musculoskeletal pain.
What is the Ojjaara dose modification program? How many times can it be used?
Patients who require a tablet dose adjustment may receive a 30-day supply of OJJAARA tablets for a newly prescribed strength at no cost. It can be used twice per lifetime.
After 1 year of maintaining stable blood level, how often can Besremi be taken?
Once every 4 weeks
Minnie Pearl's iconic hat featured a price tag with what amount on it?
$1.98
Goo Goo clusters
What was the median time to response to achieve CHR in the for Besremi in the PEGINVERA trial?
7.8 months
True or False: Ojjaara is the first & only FDA approved treatment indicated specifically for patients who have MF and anemia.
True
What is the nickname of Nashville?
Music City
In SIMPLIFY-1 what was the Total Symptom Score reduction of 50% or more at week 24 for Ojjaara and for Ruxolitinib?
25% Ojjaara
36% Ruxolitinib
What was the Duration of Response of Besremi in the PEGINVERA trial?
20.8 months
Dolly Parton
What is the NCCN recommendation for Besremi?
Preferred 1st line cytoreductive therapy option for both low risk (symptomatic) and high risk PV
In SIMPLIFY-1 the percent of patients (with anemia) achieving 35% or greater reduction from baseline in spleen volume at week 24 was for Ojjaara and Ruxolitinib?
31.4% Ojjaara
32.6% Ruxolitinib
Which park hold the world's only exact replica of the The Parthenon and which goddess statue resides inside standing at 42 feet tall?
Centennial Park, Athena