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Your best friend looks mad at you and is ignoring you but she hasn't told you why she's angry and you don't have a clue what is bothering her. What should you do?
When she looks like she's calmed down, talk about it and ask what's wrong. If she keeps giving you the silent treatment, then just find someone else to hangout with. Let her know you want to know what's wrong to try to fix it and that you're willing to talk about it with her when she's ready.