Elderly patients may be at an increased incidence of _______when treated with Avastin
Arterial Thromoembolic events
100
Based on the results of E1594, what did ECOG choose as the chemo reference standard for future trials?
Paclitaxel Carboplatin (Median OS 8m)
100
What percentage of patients in 2107 vs 966 were treated to progression or unacceptable toxicity
77% vs 29%
100
What are the 3 most common grade 3-5 AEs from E4599?
Neutropenia
Fatigue
Hypertension
100
Where does Avastin bind?
directly to VEGF extracellulary to prevent interaction with VEGF receptors on the surface on endothelial cells
200
On the basis of data from the BRiTE registry, the majority of GI perforations occur within ______months following Avastin initiation
6 months... median time 3.4 months
200
What study determined 15 mg/kg every 3 weeks until disease progression or unacceptable toxicity for Avastin and who was the primary author?
AVF0757g and Johnson
200
Across all clinical studies the incidence of GI perforation is __________
0.3 to 2.4%
200
According to the PI, how long should patients wait before initiating Avastin therapy after completiting surgery and raditiation for CNS mets?
4 weeks
200
What are the 3 proposed effects of Avastin?
Anti Vascular
Anti Angiogenesis
Anit Permeability
300
102,900 and 39,670
What are the number of people who will be diagnosed with colon and rectal cancer in 2010?
300
What are the OS results from E4599 including HR
12.3 m vs 10.3 m HR .80
300
What is the recomendation for Avastin therapy prior to and following major surgery?
Suspend 28 days prior to elective surgery
Reinititate 28 days after surgery AND wound is fully healed
300
What percentage of patients in E4599 in the Avastin PC arm recieved Avastin alone?
53% (and 50% of those recieved more than 5 cycles of Avastin alone)
300
What is the FDA approved prescibing information for the duration of Avastin treatment
Patients should continue treatment until disease progresion or unacceptable toxicity
400
In a retrospecitve subset analysis of Avastin-based therapy in 2107g, what were the HR for OS, OS, PFS, and ORR for KRAS WT
.58
27.7 vs 17.6 OS
13.5 vs 7.4 OS
60% vs 37.3%
400
What percentage of patients in E4599 had Adenocarcinoma histology?
69% (n=300)
400
What was the OS and HR for OS for Avastin+IFL vs IFL in AVF2107g
20.3m vs 15.6 m
HR=.66
400
What is the definition of continuation maintence
use of at least one of the agents given in first line, beyond 4-6 cycles, in the absence of disease progression
400
High VEGF expression may be associated with... name 3
Reduced OS
Disease Progression
Risk of relapse
Lymph node involvment
Malignant plural effusion
500
What studies are the basis for the statement "The only biologic to achieve the primary efficacy endpoints across 3 distinct IV 5FU based chemo backbones in MCRC
IRI 2107
Oxali 3200
IV 5FU 0780
500
Based on the staging guidelines at the time, describe the types of patients enrolled in E4599
wet stage IIIB and stage IV
500
What line of therapy have EGFRs shown a survival benefit
Third line
500
What percentage of lung cancers are Non Small Cell?
90%
500
What are the infusion times for Avastin for first, second and third doses