Patients with Loeys-Dietz syndrome and aortopathy have a mutation in the genes that encode these receptors.
What are TGF-βR1 and TGF-βR2?
Bonus: What type of mutation and what happens to TGF-β signaling in Loeys-Dietz?
Heterozygous loss-of-function mutation; there is paradoxical increase in TGFβ signaling resulting in increased ECM deposition degradation.

This structure of collagen fibers is a continuation of the Eustachian and Thebesian valves.
What is the tendon of Todaro?
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This surgeon in 1769 described the anterior diaphragmatic defect that carries his name.
Who is Giovanni Morgagni?
The second stage of empyema development
What is fibrinopurulent
Exudative --> fibrinopurulent --> organizing
Deep hypothermic circulatory arrest exceeding this time period should prompt consideration of adjunctive cerebral perfusion.
What is 25 minutes?
Source: STS E-book
Bonus: What are the goal flow rate and pressures for ACP and RCP?
ACP: 10 mL/kg/minute; right radial pressure of 40-70 mm Hg.
RCP: 200-300 mL/min; RIJ pressure of 25 mm Hg
This structure connects the right bundle branch to the anterior tricuspid papillary muscle.
What is the moderator band?
In 1958, this surgeon from Yale University performed the eponymous SVC-rPA anastomosis.
Who is William Glenn?
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This is the pulmonary venous drainage of an extra lobar sequestration.
What is the azygos or hemiazygos system? (IVC, portal vein, subclavian vein also acceptable).
***These are 2 absolute indications for preoperative carotid-subclavian bypass when the left subclavian artery will be covered by a TEVAR.
What are:
Patent LIMA-LAD
Hemodialysis via LUE fisutla
Dominant left vertebral artery
Prior infrarenal aortic repair with ligation of lumbar & middle sacral arteries
Planned long-segment (>20 cm) coverate of DTA where critical intercostal arteries originate
Occluded hypogastric arter
For chronic aortic aneurysms, this pharmacologic agent has been shown to have benefit in this population.
What are beta-blockers; what are patients with Marfan's syndrome?
Benefit not reproduced in other studies of adults, pediatric, with Marfan
No convincing evidence of losartan, statins, or doxycycline benefit yet in in human trials.
Source: STS-Ebook "Pathophysiology of the Thoracic Aorta); citation Shores J, Berger KR, Murphy EA, et al. Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome. N Engl J Med. 1994;330(19):1335-41
Left ventricular traction contributes to this % of right ventricular cardiac output .
What is 20-40%
This Japanese surgeon described a modification of the Norwood procedure in 2003 by replacing the BT shunt with an RV-PA conduit
Who is Shunji Sano?
***These are the 6 variables from an esophageal pH test used to calculate the DeMeester score.
What are
1. # of episodes of reflux,
2. % time < pH 4,
3. % time supine < pH 4,
4. % time upright < pH 4,
5. duration of longest reflux episode
6. # lasting > 5 minutes?
In the pathology shown here, this the most common sinus involved and the most common chamber of fistulization.

What are the right sinus and right ventricle.
Right sinus --> Right ventricle
Left sinus --> PA or left ventricle
Noncoronary sinus --> right atrium

This surgeon from Chicago performed the eponymous operation which creates a shunt from the descending throacic aorta to the left pulmonary artery
Who is William Potts?
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***These are 2 of the echocardiographic risk factors for systolic anterior motion (SAM) after mitral valve repair.
What are:
C-SPAM
C-sept distance < 25 mm
Septal thickness (basal IVS > 15 mm at end-systole)
Posterior leaflet > 15 mm
Anterior:Posterior leaflet height < 1.3
Mitral-aortic angle <120° at onset of systole
Intraop factors
Tall residual posterior leaflet (>15 mm )
Small prosthetic ring
This eponymous operation is used with D-TGA exists with LV outflow tract obstruction.
What is the Rastelli operation?