Mechanism of Action
Oral agent that directly binds to thrombin
What is dabigatran (Pradaxa)?
Rivaroxaban
What is Xarelto?
A glycopeptide used to treat methicillin-resistant Staphylococcus aureus (MRSA)
What is vancomycin?
It has a vitamin K-dependent factor concentration of 25 U/mL; much higher compared to the 1 U/mL concentration in fresh frozen plasma
What is KCentra?
The dose of 4F-PCC recommended for cardiac surgery
What is 25-50 IU/kg?
Inhibits the production of vitamin K dependent clotting factors
What is warfarin?
Clopidogrel
What is Plavix?
A topical antibiotic that decolonizes the anterior nares
What is mupirocin?
This tissue factor used to initiate the extrinsic coagulation pathway and produce thrombin, can be administered to Jehovah's Witnesses because it contains no human serum or proteins
What is recombinant activated factor VII (NovoSeven RT)?
CPB prime dose of tranexamic acid
What is 2 mg/kg?
Binds to lysine receptors on plasminogen (with 6-10 times more affinity than its counterpart) in order to inhibit activation of plasmin
What is tranexamic acid (TXA)?
Effient
What is Prasugrel?
It is known to cause seizures
What is tranexamic acid (TXA)?
The dose of 4 factor prothrombin complex concentrate for reversal bleeding secondary to cardiac surgery
What is 25-50 IU/kg?
Patient continues to bleed secondary to platelet dysfunction and you decide to administer desmopressin (DDAVP)
What is 0.3 mcg/kg (maximum 20-30 mcg) infused over 15-30 minutes?
↓ bleeding by stimulating the release of von Willebrand factor (vWF) which binds to factor VIII (this prevents factor VIII from degradation)
What is desmopressin (DDAVP)?
Eliquis
What is apixaban?
A 50% reduction in cefazolin drug concentrations secondary to CPB-induced hemodilution is caused by this pharmacokinetic change
What is reduced protein binding and increased volume of distribution?
This 4F-prothrombin complex concentrate is a good alternative for patients with heparin allergy or history of HIT
What is 4F-activated PCC (FEIBA)?
Fresh frozen plasma (FFP)
What is 10-15 ml/kg?
↑ thrombin generation by directly binding to FXa inhibitors and inhibits tissue factor pathway inhibitors (TFPI)
What is andexanet alfa (Andexxa)?
KCentra
What is 4 factor prothrombin complex concentrate?
Indicated for bleeding associated with fibrinogen deficiencies
What is cryoprecipitate?
With 35% protein binding, this direct oral anticoagulant (DOAC) can be cleared by hemodialysis
What is dabigatran?
High-dose strategy for tranexamic acid (TXA) during high-risk cardiac surgery
What is 30 mg/kg bolus followed by 16 mg/kg/hr during surgery?