Sarclisa
The dose mg/kg for Sarclisa
What is 10mg/kg body weight
How do you dose Darzalex IV?
What is dosed at 16 mg/kg using actual body weight
Is Darzalex FASPRO indicated for the same patients as Darzalex IV?
What is: The 2 products have different indications because Faspro has a different clinical program from Darzalex.
Faspro is indicated in combination with:
*Bortezomib,melphalan and prednisone in newly dx patients who are ineligible for autologous transplant.
*In combination w/lenalidomide and dex- in newly dx patients who are ineligible for auto transplant and in patients with R/R multiple myeloma who have had at least 1 prior therapy...
*In combination with bortezomib and dex with at least 1 prior therapy
* Monotherapy in patients who have received at least 3 prior lines of therapy including a PI and an immunomodulatory agent or who are double refractory to a PI and an immunomodulatory agent.
The combinations that are indicated for Darzalex IV however not for Darzalex FASPRO. 2 answers
What is DVTd, DKd and DPd
Who is the Director of Marketing for Darzalex
Who is Laura Leonetti
What is the dosing schedule for Sarclisa
What is weekly first 4 weeks then every two weeks until disease progression or death
How many indications does Darzalex IV currently have?
What is 8
Can patients who started on Darzalex IV switch to FASPRO?
What is: For approved indications DARZALEX FASPRO may be substituted for DARZALEX at the next scheduled does. However, please note that the split dose of DARZALEX is not applicable to DARZALEX FASPRO and DARZALEX FASPRO should not be used as part of the split dose regimen.
The anchor that was used in the Pegasus Study.
What is Rd
The Journal where the Pegasus Study was Published
What is American Journal of Hematology
Name how many prior lines of therapy in Sarclisa indication
What is greater than or equal to two prior lines
In the MAIA study what is the ORR for DRD vs RD?
What is 93% DRd vs 81% Rd
What is the volume of FASPRO given?
What is 15ML
Combination for transplant eligible MM patients
what is DVTd
Name three ways to give Darzalex on the first does
What is single infusion, split dose and subcutaneous administration
Combination Sarclisa is FDA approved for
What is Isa-Pd
What was the median DOR in he MAIA study?
What is: median duration of response has not yet been reached with DRD vs 34.7 months with RD
What was the median time to ARR in Darzalex FASPRO?
What is 3.7 hours
What is the combination that doses Darzalex weekly cycles 1-3, once every 3 weeks cycles 4-8, once every 4 weeks cycles 9 onwards.
What is DVD
What labs should be completed prior to giving Darzalex
What is type and screen
Name % infusion related reactions for Sarclisa
What is 38%
What was the MRD negativity rates in MAIA? DRd vs Rd
What is: The MRD negativity rate more than tripled with DRD. DRD was 24% vs RD at 7% in the MAIA study.
Can you push Darzalex FASPRO faster than the recommended 3-5 minutes?
What is: Darzalex FASPRO should be given over 3-5 minutes consistent with the PI. Consider a constant rate of pressure for the entirety of the injection.
This combination showed 9x improvement in MRD negativity vs the comparator arm at 12 months.
What is DKd
There was a nearly 3X reduction in systemic ARRs with Darzalex FASPRO vs Darzalex in the Columba trial - the % of systemic ARR for Darzalex FASPRO vs Darzalex are. The % of injection site reactions was _ %.
What is 13% vs 34 %.
What is 8%