Brand/generic
What is the generic name of Wellbutrin?
bupropion
What is the MOA of fluoxetine (Prozac)?
SSRI
What are ADR of SSRI/SNRI?
GI distress, N/V
SNRI also have slightly more HTN
activation of mania or hypomania, hyponatremia, fragility fracture, sexual dysfunction, suicidal thoughts, withdrawal syndrome, ocular effects
What BBW do all depression medications have?
suicidal thoughts and behaviors
What should you monitor for all depression medications?
suicidality/behavior changes
What is the brand name of trazadone?
Desyrel
What is the MOA of duloxetine (Cymbalta)?
SNRI
All SSRI and SNRI have this PK adjustment
hepatic
Which drug has a contraindication to allow 5 weeks to pass before initiating MAOis?
fluoxetine (Prozac) due to its long half life
What are DI of depression medications?
MAOIs within 14days, linezolid, IV methylene blue
What is the generic name of Elavil?
amitriptyline
What is the MOA of mirtazapine (Remeron)?
TetraCA - inhibits alpha 2 receptors to increase release of serotonin and NE
What CYP adjustment does the TCA (amitriptyline) have?
2D6
What are common contraindications for depression meds?
What is an important counseling point for paroxetine (Paxil)?
Has a short half-life so there are increased withdrawal symptoms with missed doses, anticholinergic effects, avoid NSAIDs and ASA and alcohol
What is the brand name of venlafaxine?
Effexor
What is the MOA of trazadone (Desyrel)?
5HT antagonist, inhibits reuptake of serotonin
What ADR does bupropion (Wellbutrin) have?
seizures, insomnia, tics, tremor, wt loss/decreased appetite, HTN, migraine
activation of mania and hypomania, suicidal thoughts, ocular effects
Which med is contraindicated during the recovery period of an MI?
amitriptyline (Elavil)
What is a patient counseling point for SNRI and SSRI medications?
Can 2-6weeks for effect
What is the generic name of Paxil?
paroxetine
What is the MOA of bupropion (Wellbutrin)?
DA and NE reuptake inhibitor
What ADR does trazadone (Desyrel) have?
cardiac arrythmias, orthostatic hypotension, priapism, morning grogginess, prolonged QTC
activation of mania or hypomania, bleed risk, serotonin syndrome, suicidal thoughts, withdrawal syndrome
What are some of bupropion (Wellbutrin) contraindications?
seizure disorder, history of anorexia or bulimia, abrupt discontinuation of ethanol or sedatives
Which medication has a patient counseling point to take doses before 2pm to avoid insomnia?
bupropion (Wellbutrin) which is very activating