“One general law, leading to the advancement of all organic beings, namely, multiply, vary, let the strongest live and the weakest die.”
Charles Darwin
Who is the current CEO of Bio-Techne? (in 2023)
Chuck Kummeth
What's the difference between totipotency and pluripotency?
Totipotent cells give rise to both the placenta, umbilical cord and the embryo while pluripotent cells can only give rise to cells in the embryo.
Why were T-Cells given their name?
T-Cells mature in the Thymus.
What is the hottest planet in the solar system?
Venus
"The cosmos is within us. We are made of star-stuff."
Carl Sagan
What was Bio-Techne's (or R&D system's at the time) first research reagent and protein?
TGF-beta
Name 2 cell types that derive from each of the three germ layers
examples
Mesoderm: heart, blood cells
Endoderm: liver, pancreas
Ectoderm: brain, skin
What are the key differences between M1 and M2 macrophages?
M1-pro-inflammatory phenotype with pathogen-killing abilities
M2-anti-inflammtory and immuno-supressive
What is Avagadro's number?
6.022*10^23
"God does not play dice with the universe."
Albert Einstein
When was Bio-Techne founded?
1976
(Partial credit for correct decade)
Name the four Yamanaka factors
Oct 3/4
Sox2
Klf4
c-Myc
What disease did David Vetter or "Bubble Boy" have?
Severed Combined Immune Deficiency (SCID)
What is the approximate age of the universe?
14 (13.8-9) billions years
"Those who would give up essential Liberty, to purchase a little temporary Safety, deserve neither Liberty nor Safety."
Benjamin Franklin
Approximately how many goats are on Bio-Techne's polyclonal goat antibody producing goat farm?
270
What foundation named after a sci-fi icon supports stem cell research?
The Roddenberry Foundation
What early marker is present on both T and NK cells and suggests that precursor cells have committed to the lymphocyte lineage?
CD7
Who was the first woman to win the a Nobel Prize in science?
Marie Curie.
She was also the first person to win a Nobel prize period. She won a Nobel Prize first in physics and then in chemistry. Her daughter also won a Nobel prize in chemistry.
"Science and everyday life cannot and should not be separated. Science, for me, gives a partial explanation of life."
Rosalind Franklin
Tc-Buster originated in what lab from UMN?
Bonus: What insect is Tc-Buster isolated from?
Branden Moriarity, PhD
Bonus: Red flour beetle
In a breakthrough for personalized medicine, Hans Clevers and team first used intestinal organoids to test the efficiency of which drug for a patient with which disease?
(partial credit for drug or disease)
Kalydeco/Ivacaftor, Cystic Fibrosis
Who was the first child to be treated with CAR-T therapy?
Emily Whitehead
Why are individuals with Rett syndrome almost always female?
Rett syndrome is X-linked and boys with only one X chromosome and the mutation (MeCP2) almost always die before birth.