Compounding Dermatological Products
Ointment Bases
Not Just Another Ointment
What You Know About Ointments?
Etc.
100
A formulation that releases an active drug to the application site.
What is topical vehicle or formulation?
100
An ointment base composed of only hydrocarbon chains or oil compounds
What is an oleaginous base?
100
This topical preparation is composed of at least one liquid and a thickening agent. It is also made up of a colloidal system that has a network of solvated particles.
What is a gel?
100
Dermatological formulations are among the most frequently compounded products. Protectant, emollient, & lubricant are all _________ of ointments?
What are uses of ointments?
100
This dermatological product is designed to deliver drugs to the systemic circulation. To achieve this, permeation enhancers are added.
What is the transdermal drug delivery system?
200
To provide skin softening effects by hydrating the skin
What is an emollient?
200
This ointment base can be hydrous or anhydrous.
What is a water miscible base?
200
Jason Taylor has a dermatological condition that leaves his skin very dry and irritated. The Pharmacist notices that his skin is oozing and weeping. This is the topical vehicle most appropriate to administer zinc oxide for the treatment of Mr. Taylor’s condition.
What is a paste?
200
Ointment bases are differentiated on the basis of their physical composition:Therefore, Oleaginous Absorption W/O Emulsion O/W Emulsion Water Miscible These are .................
What are types or classes of ointment bases?
200
A physician asks you to create an ointment that meets the following specifications: The ointment contains a very lipophilic drug The ointment should provide a rapid release of the drug Hint: This base is the only one that can be hydrous or anhydrous
What is a water miscible ointment?
300
Method of application Relative affinity of drug for base and skin Condition of skin Are all parameters that _______
What are factors affecting the absorption of drugs from ointments?
300
These ointment bases have occlusive properties and can be used as protectants.
What are oleaginous & absorption bases?
300
Structurally similar to gels but they contain a higher content of liquid (i.e. water), and are usually less viscous.
What is a jellie?
300
This pharmaceutical compounding tool is used when the final product contains Tannic Acid, Mercury Salts, Iodine or other corrosive materials.
What is a plastic spatula?
300
This medicament, in most instances is unstable in the presence of moisture. Therefore, is compounded using am Anhydrous Ointment Base (i.e. Petrolatum rather than Emulsion Type)
What are antibiotics?
400
Pharmaceutical technique used when compounding ointments
What is geometric dilution?
400
Understanding an ointment bases affinity for water is important. Identify the ointment bases that are water loving or hydrophilic.
What are absorption, emulsion, and water miscible bases?
400
This formulation is composed of macromolecules distributed in such a manner that no boundaries exist between them and the liquid (Homogenously dispersed)
What is a single phase gel?
400
A Semi-Solid Emulsion of O/W or W/O type used as bases or vehicles for drugs intended for topical use.
What is a cream?
400
Fill in the blank: Water/oil emulsions are composed of oleaginous materials and _____ (w/w) water, while oil/water emulsions are composed of oleaginous materials and ____ (w/w) water.
What is <45%, >45%?
500
An ointment base property that distinguishes if the base is anhydrous or hydrous.
What is the water content?
500
Mix drug with absorption base to form a paste, incorporate paste into the base via geometric dilution, account for absorption base used to yield the correct dispensing quantity
What is the procedure used to compound an ointment containing a liquid?
500
This pharmaceutical formulation is produced when the gel mass consists of floccules or small distinct particles of colloidal dimensions (Polyphase)
What are milks and magmas?
500
Water Content (anhydrous or hydrous) Affinity for Water (hydrophilic or hydrophobic) Spreadability (easy – difficult) Washability (washable or non-washable) Greasiness (greasy or non-greasy) Drug Release Potential (poor - good) Occlusiveness (yes or no) Uses
What are classifications of ointments?
500
These drug entities can be incorporated salt or free form. If Salt, dissolve in small amount of water—Take up into Absorption Base (Aquaphor or Refined Wool Fat) There is usually a Heat Stability Problem
What are alkaloids?
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