Prevalence of CKD
5 million people
How many people are at risk of CKD?
A GFR of <60ml/min for >3 months, with or without kidney damage or evidence of kidney damage with or without decreased GFR for > 3 months
What is chronic kidney disease?
Hundreds
How many genes are implicated in CKD?
diabetes and hypertension
What are the most common comorbidities of CKD?
1 in 5
How many first nations people have CKD?
Northern territory
What Australian state has the highest prevalence of CKD?
Up to 90%
How much kidney function can you lose before experiencing symptoms?
Autosomal dominant polycystic kidney disease (ADPKD)
What is the most common genetic cause of CKD?
Increases blood pressure and fluid retention, causing further damage to the kidneys
How does high sodium intake influence CKD development?
Yearly
How often should First Nations Individuals be screened for kidney disease?
less than 10% of people
What percentage of people are aware they have CKD?
10 years for deceased donor, 15 years for living donor
How long does a transplanted kidney last?
Mutations in PKD1 or PKD2
What causes ADPKD?
High glucose damages the kidneys nephrons
How does diabetes contribute to CKD?
Over 18
What age should Indigenous people be screened for CKD?
5.6 million Australians
How many Australian's have one or more CKD, CVD, or T2D?
Permanent damage from initial injury, fibrosis and inflammation
Why does AKI often lead to CKD?
Family members also suffer from the gene and are unable to donate
Why do those with PKD often rely on deceased donors?
Increases the risk of hypertension, diabetes, and obesity, overall increasing CKD risk
How does reduced sleep increase CKD risk?
Indigenous status
What has recently been removed as a risk factor for CKD?
Socioeconomic status
What is one of the greatest factors that impacts rates of CKD?
Approximate GFR of <10ml/min
When does a CKD patient require dialysis?
A gene variants common in people of African heritage, linked to increased risk of kidney disease
What is the APOL1 genetic variant?
Chronic hypoxia, inflammation, and SNS activation can cause kidney damage
How does OSA influence CKD?
Due to presence of other comorbidities
Why are Indigenous individuals often not listed on the transplant list?