Pathophysiology
Disorder of what gland
Posterior Pituitary
2 P's of DI
Polyuria and Polydipsia
Urine output in a 24-hour period
greater than 4L or more than volume ingested
Hydration
Oral and IV
Water loss is caused by
ADH deficiency or an inability of the kidneys to respond to ADH.
Skin S/Sx
poor skin turgor, dry or cracked mucous membranes
specific gravity
less than 1.005
Drug Therapy
Desmopressin
Leads to:
polyuria, dehydration, and disturbed fluid and electrolyte balance.
Kidney/Urinary S/Sx
increased urine output, dilute low specific gravity
osmolarity
50-200mOsm/kg
diet
low sodium
3 Classifications of ADH
Cardiovascular S/Sx
hypotension, tachycardia, weak peripheral pulses, hemoconcentration
Osmolality
50-200mOsm/L
2 things to monitor
daily weight and I&O
Drugs that cause DI
Lithium carbonate and demeclocycline
Neurologic S/Sx
decreased cognition, ataxia, irritability
Lab test to monitor
BMP, CBC, Urinalysis
Education for Drug Therapy
HEADACHES
S/Sx of dehydration
S/Sx of fluid volume overload
medical alert bracelet