Pharmaco
What is MOA of digoxin?
Na-K pump inhibitor
Effect of metoclopramide
decrease rate and extent
How many compartment
two-compartments
Main excretion route?
Kidney
Characteristic ADR
change in colored halos around objects : involving yellow‐ green spectrum
2 Indications of digoxin
AF and CHF
Effect of antacid
decreased extent
Sampling time for oral
> 6 hours
How change the Half-life in CKD
longer
CVS ADR
Brdaycardia, AV block
Therapeutic range (mcg/L)
0.5-2.0 mcg/L
Effect of rifampicin
Decrease extent
Sampling time for IV
> 4 hours
Effect of hyperthyroid
increased CL 1.3%
Tablets
0.7
Cp: increased ADR
greater than 2.0 mcg/L
Effect of Grapefruit juice
increase extent
Effect of CKD on Vd
decreased Vd
Effect of amiodarone
decreased CL 50%
Syrups
0.8
Cp: toxicity
greater than 2.5 mcg/L
Effect of ATB
increased extent
Effect of hypothyroid on Vd
Decreased
Role of acidic pH in GI tract
Cleave sugar
Soft gelatin
1