Foundations
This hypothesis assumes that chemotherapy kills a constant proportion of cells (first-order kinetics) rather than a constant number
What is the Log-Kill Hypothesis (or Fractional Kill Hypothesis)
This toxic metabolite of ifosfamide and cyclophosphamide is responsible for causing hemorrhagic cystitis
What is Acrolein?
This oral pyrimidine analogue is a prodrug of 5-Fluorouracil (5-FU)
What is Capecitabine?
These microtubule "stabilizers" promote assembly and inhibit disassembly, effectively freezing the cell in metaphase
What are Taxanes?
This agent is used to manage ifosfamide-induced neurotoxicity by decreasing the formation of acetaldehyde
What is Methylene blue?
This mathematical model predicts that the probability of developing drug resistance increases with tumor volume or the number of mitoses
What is the Goldie-Coldman Hypothesis?
This platinum analogue is notorious for causing acute neurotoxicity that is triggered or exacerbated by exposure to cold
What is Oxaliplatin?
Patients with a genetic deficiency in this enzyme are at risk for life-threatening toxicity from 5-FU or capecitabine
What is Dihydropyrimidine dehydrogenase (DPD)?
This chronic, dose-dependent toxicity of anthracyclines requires a cardiac echo assessment before and during treatment
What is Cardiomyopathy?
To prevent this ocular side effect of Cytarabine, patients should be given prophylactic steroid eye drops
What is Conjunctivitis?
This treatment modality involves administering chemotherapy before primary surgery to reduce tumor volume
What is Neoadjuvant therapy?
This agent must always be administered with ifosfamide to detoxify acrolein in the bladder. Give both names for it.
What is MESNA (2-mercaptoethane sulfonate)
Leuocovorin can be given to "rescue" high doses of methotrexate. What's the other drug that can do this?
What is Glucardipase?
What type of cell-cycle class inhibitor is Bleomycin?
What is Cell cycle G2-specific?
In 1943, sailors in Bari, Italy were exposed to what toxic compound AND what side effect did they see?
What is nitrogen mustards and depletion of bone marrow stores (& lymph nodes)