Avastin in TML
Avastin Safety
Competitive CRC
Avastin PI
Potpourri
100
The median OS for the chemotherapy plus Avastin arm in ML18147 (measured from time of randomization)?
What is 11.2 months?
100
3 Boxed Warnings in the Avastin Package Insert
What are: GI Perforation, Surgery/Wound Healing Complications, Hemorrhage?
100
Two major side effects experienced by patients treated with anti-EGFR inhibitors
What are Rash and Diarrhea?
100
Avastin is currently indicated for six tumor types. Please give the answer in entire words vs. acronyms
What are: 1. metastatic colorectal cancer 2. non-squamous non-small cell lung cancer 3. glioblastoma 4. metastatic renal cell carcinoma 5. persistent, recurrent or metastatic Cervical Cancer 6. Platinum-resistant recurrent epithelial Ovarian, Fallopian tube or primary peritoneal cancer ( prOC)
100
Bob Swanson & Herb Bauer
Who are the founders of Genentech?
200
How was it determined if oxaliplatin- or irinotecan-containing chemotherapy was used in 2L in the ML18147 trial or TML study
What is, If the investigator used Iri in 1L, then Oxali was used in 2L, and vice versa?
200
Serious or fatal pulmonary hemorrhage occurred in four of 13 (31%) patients with this type of histology
What is Squamous?
200
According to the Erbitux Package Insert, there is no evidence of effectiveness in this subgroup of patients
What are patients with K-ras mutation-positive tumors?
200
The Avastin PI contains three Boxed Warnings
What are: 1. Gastrointestinal Perforations 2. Wound Healing Complications 3. Hemorrhage
200
2004
What is the year the FDA approved Avastin for 1L treatment of mCRC?
300
In ML18147, the effect of continuing Avastin beyond first progression was dependent on K-ras mutation status. “True or False”
What is False?
300
According to the PI, 1 of 4 situations when Avastin should be temporarily suspended
What are: 1. At least 4 weeks prior to elective surgery, or 2. Severe HTN not controlled with medical management, or 3. Moderate to severe proteinuria pending further evaluation, or 4. Severe infusion reactions
300
In 2014 Erbitux + __________ - based chemotherapy was added to NCCN guidelines; reversing a previous note in 2011 citing detrimental affects of its use in combination with this chemo.
What is Erbitux + oxaliplatin based chemotherapy?
300
Dose modifications and contraindications for Avastin
What is "none?"
300
The number of different variations of fluoropyrimidiene-based chemotherapy received by patients enrolled in the TML study
What is more than 8?
400
The registry that was the first to provide evidence that continuing Avastin during subsequent chemotherapy after first disease progression results in prolonged OS relative to chemotherapy alone
What is "BRITE?"
400
The level of protienuria at which Avastin should be suspended
What is >2 grams/ 24 hours?
400
The primary endpoint from the FIRE-3 study
What is ORR?
400
5 of 11 Warnings or Precautions for Avastin in the Package Insert
What are: 1. GI perforations and Fistulae 2. Non-Gastrointestinal Fistulae 3. Surgery and Wound Healing Complications 4. Hemorrhage 5. Arterial Thromboembolic Events 6. Venous Thromboembolic Events 7. Hypertension 8. Posterior Reversible Encephalopathy Syndrome (PRES) 9. Proteinuria 10. Infusion Reactions 11. Ovarian Failure
400
Vectibix and Erbitux are in what class of drugs? Do both of these drugs have a limitation of use in their labels? Does Avastin have a limitation of use?
a. What are Anti-EGFR's b. What is True? c. yes, not indicated for Adjuvant treatment in Colon cancer
500
One of the dosing regimens used in ML18147?
What is either; 5mg/kg q2w or 7.5mg/kg q3w?
500
The incidence of GI Perforation across clinical studies, according to the Avastin PI
What is 0.3 - 3.2%?
500
3 biologics that are FDA and NCCN approved for first line use in mCRC
What is Avastin, Vectibix and ERbitux.
500
Three recommended doses and schedules for Avastin in mCRC
What are: 1. 5 mg/kg q2w with bolus-IFL. 2. 10 mg/kg q2w with FOLFOX4. 3. 5 mg/kg q2w or 7.5 mg/kg q3w in combination w/5FU-irino or -oxali based chemo in pts who have progressed on 1L Avastin-containing regimen.
500
In the past 3 years, Erbitux trials have failed to show superiority over Avastin in 1st line mCRC. What are the 2 trials and what were the Primary endpoints in each?
What is Fire-3---ORR and 80405---OS
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