Drugs/Treatment
Rashes
Signs and Criteria
Timeline
Final Jeopardy
100
First step to treat drug rash and fever
What is discontinue the drug?
100
What is SJS/TEN?
100
Minimum percent of skin involvement to diagnosis TEN
What is >30%?
100
This presents like NMS in a more acute (within 24 hours) period
What is serotonin syndrome?
200
DOC to treat a febrile condition induced by succinylcholine or volatile anesthetic
What is dantrolene?
200
What is erythema multiforme?
200
The set of criteria is used to diagnose serotonin syndrome
What are the Hunter Toxicity Criteria Decision Rules?
200
This condition presents with an acute phase of 8-12 days and re-epithelialization in 2-4 weeks
What is SJS/TEN?
300
Wound care techniques used in SJS/TEN
What are antishear therapy and whirlpool therapy?
300
This condition presents with sterile pustules overlying a rash
What is AGEP?
300
Gentle pressure on surface of affected skin causes spread of tissue sloughing
What is Nikolsky's sign?
300
This drug rash has an onset of 1-14 days and resolves in 5-14 days
What is exanthematous drug eruption?
300
The pathogenesis of DRESS is hypothesized to be an interaction between these 3 things
1. Enzyme deficiency allows drug metabolites to build up, causing cell death or triggering an immune response
2. Certain HLA subtypes are susceptible to drug hypersensitivity
3. Potential interaction between a latent viral infection and the drug
400
Allopurinol is known to induce these two drug reactions
What are TEN and DRESS?
400
Condition characterized by pruritic maculopapular erythematous rash on the truck and extremities
What is exanthematous drug eruption?
400
NMS is characterized by AMS, fever, autonomic instability, and this muscle sign
What is lead pipe rigidity?
400
Name 3 of the 5 patterns of presentation of MH
What are immediately after drug administration, intraoperatively, minutes after drug cessation, postoperatively, “recrudescence” in 25% of patients?
500
Last resort treatment of serotonin syndrome
What is cyproheptadine?
500
Areas normally spared by SJS/TEN
What are the scalp, palms, and soles?
500
This is used on day 1 and day 3 after presentation to evaluate the severity of SJS/TEN
What is the SCORTEN score?
500
EM symptoms develop over _____ days and last ____ weeks
What is 3-5 days and 2 weeks?