drugs

atypical antidepressants

100

toxicity of this drug: 

Stimulant effects (tachycardia, insomnia), headache, seizures in anorexic/bulimic patients.

May help alleviate sexual dysfunction.

Bupropion

200

Toxicity of this drug: Sedation, increased appetite, weight gain  dry mouth.

Mirtazapine

alpha-2 -antagonist

300

Primarily blocks 5-HT2, α1, and H1 receptors

Used primarily for insomnia, as high doses are needed for antidepressant effects. 

Trazodone

400

Varenicline method of action?

 Nicotinic ACh receptor partial agonist.

Used for smoking cessation

500

Vilazodone MOA?

Inhibits 5-HT reuptake; 5-HT1A receptor partial agonist. 

Used for major depressive disorder &  generalized anxiety disorder (off-label)

typical antipsychotics

100

indications?

Schizophrenia (primary positive symptoms)

Psychosis

Bipolar disorder

Delirium

Tourette syndrome

Huntington disease,

OCD

200

dangerous side effect of all of them??

Neuroleptic malignant syndrome (NMS)

Mental status change

Autonomic instability

Fever, rigid, confusion 

Myoglobinuria, high CK

Encephalopathy, 

Treatment: dantrolene, bromocriptine

300

High potency ones?

Low potency ones?

High potency: Trifluoperazine, Fluphenazine, Haloperidol 

"Try to Fly High" —neurologic side effects

 

Low potency: Chlorpromazine, Thioridazine 

"Cheating Thieves are low"—anticholinergic, antihistamine, α1-blockade effects.

400

Ophthalmologic side effects? (thinking of 2 drugs): 

Chlorpromazine—Corneal deposits

Thioridazine—reTinal

500

differences between neuroleptic malignant syndrome & serotonin syndrome? (Thinking of 2)

onset: neuroleptic malignant syndrome (1-3 days)  and serotonin syndrome (<1 day)

reflexes: NMS (hyporeflexia, diffuse rigidity "lead pipe") and SS (clonus, hyperreflexia)

atypical antipsychotics + indications

100

which sx of schizophrenia do they treat?

+ and - 

200

cardiac side effect?

hematologic side effect?

cardiac side effects: all prolonged QT interval

clozapine- agranulocytosis 

300

tourette syndrome?

antipsychotics (fluphenazine & risperidone), tetrabenazine

400

bulimia nervosa: drug of choice and contraindicated drug

use: SSRIS (fluoxetine)

don't use: bupropion due to seizure risk

500

alcoholism tx

disulfiram

Acamprosate (reduce desire to drink)

Naltrexone (reduces cravings)

Supportive care

therapy :) 

seizure drugs

100

Blocks thalamic T-type Ca2+ channels

Ethosuximide

200

Also for eclampsia seizures (1st line is MgSO4)

Benzodiazepines

300

1st line in neonates,  increase GABA-A action

Phenobarbital

400

1st line for trigeminal neuralgia, blocks Na+ channels

Carbamazepine

500

Also used for migraine prevention

Topiramate

randos

100

benzos you can use in patients wtih liver disease 

oxazepam

temazepam

lorazepam

"OTL are OK for Terrible Livers"

200

Barbiturates impact on CYP450?

induces CYP450

300

used to treat acute migraine, cluster headache attacks but can cause coronary vasospasms

Sumatriptan

400

Orexin (hypocretin) receptor antagonist used to treat insomnia

Suvorexant

500

Treatment for ALS that modestly increases survival

by decreasing glutamate excitotoxicity via an unclear

mechanism

Riluzole