Side Effects
Myopathy
What is a shared side effect of both statins and fibrates?
A BEAM MOA
DOUBLE POINTS if you can name them
What is a selective b1 blocker?
Atenolol
Betaxolol
Esmolol
Acebutolol
Metoprolol
Everything we know about statins
What is: very good at decreasing LDL
inhibits HMGCOa reductase to decrease cholesterol synthesis
Decrease mortality in HF patients
Causes hepatotoxicty and myopathy
Very decreased LDL
Slightly increased HDL
Slightly decreased Triglycerides
What are PCSK9 inhibitors? (alirocumab, evolocumab)
The best agent for lowering LDL cholesterol
Statins
Myalgia, delerium, dementia
What are the side effects of PCSK9 inhibitors?
Blocks cholesterol resorption
What are bile acid resins?
Everything we know about niacin
Best at increasing HDL, lowers LDL and triglycerides also
Side effects include flushing, warmth, hyperglycemia, hyperuricemia (gout)
Decreased LDL
Slightly increased HDL
Slightly increased triglycerides
What are bile acid resins? (cholestyramine, colesevelam, colestipol)
Treats angina, arrythmias, HTN, thyroid storm
The side effects of bile acid sequestrants...including contraindications
What are:
Contra: hypertriglyceridemia, diverticulitis
GI upset (const./bloating), FSV malabsorption (can lead to bleeding), gallstones
Fibrates....
Bempedoic acid
What is: inhibits ATP-citrate lyase
Reduces de novo cholesterol synthesis
Used when statin intolerant
Causes URIs, muscle spasm, back pain, anemia
Don't use if pregnant or lactating
Slight decrease in LDL
Slight increase in HDL
Significant decrease in triglycerides
Bonus: What else has this exact effect?
The difference in medication log. charts for competitive vs noncompetitive inhibitors
What is: right shift for competitive, downward shift for noncompetitive (irreversible)?
Bonus: which adrenergic drugs would this apply to?
A med that seems like it could be used for HF but shouldn't....
What is acebutolol (partial a1 agonist activity)?
What are: Phentolamine a1/a2
Phenoxybenzamine a1/a2 (irreversible)
Prazosin a1
Tamusolin a1A
Everything we know about beta blockers
What is: (I really don't feel like writing this out so we can just talk about it and then check it in my notes lol......)
hehe this is the last clue I made and I am tired :)
Slight increase in LDL and HDL
Decreases triglycerides
What is fish oil? (must be in high doses)
Would worsen COPD/asthma
What are B2 blockers?
Anaphylaxis
What is a side effect of fish oil/vitamin b3?
Shared characteristics between Ezetimibe and bile acid resins
What are inhibitors that act in the intestinal lumen
All adrenergic agonists (name and receptors)
What are: epinephrine (all), norepinephrine (all but b2), isoproterolol (b1/b2), dobutamine (b1), dopamine (a1,b1,dop), ephedrine (all), phenylephrine (a1), albuterol (b2), and clonidine (a2)?
Best at improving good cholesterol
What is niacin?
CHF drugs/agents with mortality benefit
ARNIs, ACEs, ARBS, B-blockers (esp. ABEAM and carvedilol), spiro/eplerenone, SGLT-2