Drug Mechanism
Diazepam
GABA A PAM
Propranolol
Essential tremor
Levodopa (at least 1)
GI, hypotension, sleepy
Entacapone
Peripheral COMT inhibitor
Baclofen
GABA B agonist
Sumatriptan
Binds 5-HT 1B/1D to prevent CGRP release
Ethosuximide
Absence seizures
Tizanidine (at least 2)
hypotension, dry mouth, hepatotoxicity, drowsy
Verapamil
CC blocker
Tetrabenazine
VMAT 2 inhibitor
Topiramate (need at least 3)
inhibits Na+ channels, binds GABA receptor, prevents calcium influx, carbonic anhydrase inhibitor
Dantrolene (at least 1)
spasticity and malignant hyperthermia
Topiramate (at least 1)
Tingling/Numbness, mental dullness, kidney stones
Ethosuximide
Blocks T-type CC
Stabilize Na+ in inactive state, inhibit glutamate release, inhibit T-type CC
Trihexyphenidyl
anticholinergic
Risperidone (bonus: in what kind of patients)
Huntington's in depressed patients
Valproate (at least 2)
Weight gain, tremor, hyperammonia, liver failure, bone marrow suppression
Dantrolene
Ryanodine receptor antagonist
Rimegepant
CGRP antagonist
Riluzole
Decreases glutamate induced excitotoxicity
Phenytoin (at least 2)
focal seizures and status epilepticus
Amantadine (2)
Anticholinergic and levido reticularis
Cyclobenzaprine
Similar to TCAs, inhibits MSR
Valproate (at least 2)
inactivate Na+ channels, decrease Ca2+ influx, increase GABA