Drugs for CMS Disorders

Multiple Sclerosis

100

Administered Parenterally SQ or IM

Interferon Beta

200

Elevated LFTs: monitor liver labs

Methotrexate

300

Drug causes flu like symptoms and headaches

Interferon Beta

400

This drug is indicated for psoriasis, rheumatoid arthritis, and other autoimmune conditions

Methotrexate

500

This drug is toxic to frequently dividing cells and causes Bone Marrow Suppression (CBC)

Mitoxantrone

Muscle Spasm

100

Also known as Valium

Diazepam

200

Treats muscle spasms

Cyclobenzaprine

300

Spasticity drug that acts directly on skeletal muscles

Dantrolene

400

This drug acts within the spinal cord to suppress hyperactive reflexes

Baclofen

500

Antidepressants increase risk for serotonin syndrome; tolerance and dependence can develop

Cyclobenzaprine

Alzheimers

100

Can be used at any stage of Alzheimers and PD related dementia

Rivastigmine

200

Goal is to slow disease progression

Donepezil

300

Improved cognitive function tests and better day-to-day functioning

Memantine

400

Reversibly prevents the breakdown of acetylcholine by the enzyme acetylcholinesterase

Rivastigmine

500

These two drugs include GI N/V/D and dyspepsia as adverse effects

Donepezil and Rivastigmine

Parkinsons

100

Induces sleep attacks and nightmares

Pramipexole

200

MAOI interaction can cause hypertensive crisis

Levodopa

300

only given with levodopa and carbidopa (Stavelo)

Entacapone

400

With mostly elevated levodopa levels, drug effects include rhabdomyolysis and liver failure

Entacapone

500

Only available in combo with carbidopa or in combo with carbidopa and entacapone; does not cross BBB

Levodopa

Seizures

100

Treats only partial seizures

Oxcarbazepine

200

Effect include rash that looks like measles

Phenytoin

300

Enhances and mimics the effects of GABA

Phenobarbital

400

Absorption varies if given IV or PO; NTI 10-20mcg/mL

Phenytoin

500

Widely used for all major seizure types, also bipolar disorder and migraines

Valproic Acid