Patterns
R-ratio >5 suggests what pattern?
Hepatocellular
Most common cause of mild elevated LFTs in US?
NAFLD
Normal ALT cutoff in females is?
19-25 IU/L
C282Y mutation is linked to?
Hemochromatosis
AST/ALT rise 2-3 days after overdose of?
Acetaminophen
AST/ALT >2 is classic for what?
Alcoholic Hepatitis
Autoimmune hepatitis is associated with what gender predominance?
Female
Why is the term "LFT" a misnomer for AST and ALT?
Elevation is a sign of liver injury, not with the function of the liver
Alpha 1 antitrypsin also causes disease in which organ?
Lungs (emphysema)
Name on anti-TB drug causing DILI
Possible answers:
- Isoniazid
- Rifampin
-Pyrazinamide
ALP + Bilirbuin > AST/ALT pattern is?
Cholestatic
•Which condition is linked with US in 50% of cases?
Primary Sclerosing Cholangitis
Which antibody is seen in PBC
Anti-mitochondrial Ab
Wilson's gene mutation is on what gene?
ATP7B
Possible answers:
- valproic acid
- carbamazepine
- phenytoin
How many times above the upper limit of normal can LFTs be elevated and still considered "mild"
5 times
Celiac disease LFTs normalize after how long gluten-free?
1 year
Why is ALP elevated in pregnancy?
Most common A1AT disease genotype?
ZZ Homozygous
ALT predominant elevation
Which lab helps confirm hepatic vs bone source of ALP?
Drug-induced liver injury from antibiotics is most common with?
Augmentin
Best lab for predicting CBD stones?
GGT
What % of emergent liver transplants due to Wilsons?
6-12%
Alcohol is toxic to which organelle in hepatocytes?
Mitochondria