Lifetime 1
Name the Journal that "Lifetime impact of achondroplasia: Current evidence and perspectives on the natural history" was published in.
What is Bone?
The author is:
Who is Julie-Hoover Fong?
The number of Achondroplasia experts that met to discuss ACH.
What is 14?
The percent of adult patients with ACH that report poor ambulation.
What is 13%?
_____ percent of adults with ACH cant complete basic activities of daily living.
What is 11%?
Overall percent of chronic pain is _____ which is _____ times higher that the general population.
What is 64% and 3 times?
The most common area of pain found by the LPA survey is the _____.
What is the back?
Babies with ACH are born with smaller or larger foramen magnum.
What is smaller?
The risk of sudden death in children under the age of 5 is _____ times higher than the general population.
What is 50?
In a study of 114 ACH patients treated at US Skeletal Dysplasia clinics, ____% of those imaged were found to have foramen magnum stenosis.
What is 47%?
The date of this publication is:
What is Feb 2021?
To assess head circumference growth, it is essential to plot this measurement on a _____________.
What is an achondroplasia specific chart?
Hydrocephalus occurs with a prevalence of ____to ____.
What is 15 to 20?
Transient, mobile kyphosis is seen in _____ of infants under 1 year of age.
What is 90?
20% by age 20 and 80% by age 60
Retrospective studies have shown ____ % of children with achondroplasia have PSG-diagnosed obstructive sleep apnea (OSA).
What is >50?
__________ is a hallmark of ACH and may progress rapidly during age _____ to _____.
What is Genu Varum and 3 to 4?
The PDUFA date of Voxzogo.
What is November 20?
Name 3 tools to assess potential complications of foramen magnum compression.
What are:
overnight sleep study
MRI of brain and cericomedullary junction
complete physical exam
_____ can exacerbate complications in ACH such as ___, ____, and ____.
What is excess weight, OSA, spinal stenosis and leg deformities.
Macroencephaly is a hallmark clinical feature of ACH caused by _____ _____ _____ _____ together with increased CSF in the _____ ______ _____.
What is increased brain tissue volume and cortical subarachnoid space?
About _____% of patients with achondroplasia have malalignment that warrants corrective surgery.
What is 17?
By _____ years of age, ACH children have achieved _____% of their adult head circumference.
What is 2 and 90%?
Name 5 of the 10 functional consequences of ACH in Infancy.
What are
gross motor delay
hypotonia with weakness
ventriculomegaly
foramen magnum stenosis
hearing difficulty
sudden death
kyphosis
cervicomedullary compression
upper airway obstruction
sleep disordered breathing
otitis media/chronic middle ear fluid
In adult ACH patients, almost _____% have legs that are shorter than average stature and arm span is shorter than ____% of the general population.
What is 50 and 35?