Antibodies
Name 2 Antibodies in Mayo’s Movement Disorder Panel that are Unique to Mayo
9 Antibodies
(GFAP,GRAF1,NIF,Septin5, Septin7,AP3B2,TRIM46
Neurochondrin,PDE10A)
ARUP AND Labcorp offer a Stiff Person Evaluation without this key antibody
GlyR
This most common Hypokinetic (not enough or slow movement) disorder sometimes also has Hyperkinetic features
Parkinsonism
What is the test code for Movement Disorders?
MDS2/MDC2
What evaluation is underpowered to detect the antibodies clinically relevant in Autoimmune Disorders?
PAVAL
This antibody is associated with testicular cancer rate of ~70% and the Olmstead Study predicts it is likely to be one of the
most common biomarkers of paraneoplastic syndromes found in men
Kelch 11
This Lab updated their mimic Movement Disorder Panel to include Kelch11 and Ma2 in April 2025
ARUP
Outdated name for Stiff Person Spectrum Disorders
Stiff Man Syndrome
Which method is recommended to order? (Serum/CSF/Both)
Both
True or False:
MCLs Movment Disorder test offers no reflexes.
False
This antibody now is available only as a standalone test but will soon be added to the Movement Disorder Panel
Ma2
This lab offers a Paraneoplastic/Stiff Person Profile with Amphiphysin, CRMP5 and ANNA-1
Athena
With this phenotype, Hearing loss and tinnitus may precede other neurological signs and symptoms by weeks to
months.
Anti- Kelch11 Encephalitis
How many mLs are collected for optimal antibody detection?
4mLs
Name 3 specialists who evaluates for Movement Disorders?
General Neuro, Movement Disorder Specialist, Hospitalist, Neuro Immunologist, Neurohospitalist, Neuro Ophthalmologist
This antibody, that has a 90% association with small cell lung carcinoma, thymoma, thyroid or renal carcinoma is tested by Mayo by Western Blot w/ reflex to Tissue IFA if positive
CRMP5
This lab has a very limited Autoimmune Ataxia Panel that only includes P/Q Type VGCC, Tissue Transglutimase Ab IGA, Yo Ab and Immunoglobulin A
Quest Diagnostics
In the world of Movement Disorders, PERM stands for this:
Progressive Encephalomyelitis with Rigidity and Myoclonus
What assay method is used/performed for Movement Disorders to screen for patterns?
Immunofluorescence Assay (IFA)
This classic movment disorder is characterized by resting tremor, bradykinisia, rigidity, and postural instability
What is Parkinson’s Disease
This antibody is in the serum version of our panel but not the CSF verison
P/Q Type VGCC
Our competitors tout they offer more stand alone tests than Mayo but with this test Mayo Clients can order any stand alone antibody if patient has tested + for that antibody with Mayo in last 5 years
Paraneoplastic Evaluation follow up
PNEFS/PNEFC
Name 2 Types of Hyperkinetic Movement Traits
• Chorea
• Myoclonus
• Dystonia
• Tics
• Dyskinesia
Why is it important to collect the sample before a patient begins immunosuppressive therapy?
Treatments could reduce or mask the antibodies, making the test less accurate
This inherited movement disorder causes chorea, cognitive decline, and psychiatric symptoms?
What is Huntington’s Disease