Secret Agents
Magnum "P.I." Facts
Dose of Reality
VTE Pathophysiology
Home Studies-Eliquis Trials
100
Coumadin
What is Warfarin
100
P.I.(s) with Boxed warning for Premature Discontinuation and Spinal/Epidural Hematoma?
What is Eliquis, Pradaxa, and Xarelto
100
In the Pradaxa P.I., what is recommended dosing regimen for the treatment of DVT/PE?
What is For patients with CrCl >30 mL/min, the recommended dose of Pradaxa is 150 mg taken orally, twice daily, after 5-10 days of parenteral anticoagulation.
100
Abnormal blood flow, hypercoagulability, endothelial dysfunction
What are the elements of the Virchow Triad
100
This study looked at patients after elective hip replacement surgery
What is ADVANCE 3
200
Xarelto
What is Rivaroxaban
200
In the Xarelto P.I. what were the number of CRNM Bleeds in each arm of the Einstein DVT/PE?
What is 357 in both arms
200
In the Eliquis P.I., what is the dose adjustment for patients with moderate renal impairment following hip/knee replacement surgery?
What is NO DOSE ADJUSTMENT REQUIRED
200
Name 2 deep veins above the knee
What is Popliteal, femoral, or iliac
200
What were the primary efficacy endpoint/outcome results in ADVANCE 2?
What is Eliquis was not only noninferior but also superior to enoxaparin for the composite of total DVT, nonfatal PE and all cause mortality
300
Lovenox
What is Enoxaparin
300
In the Elliquis P.I., what were the rates of Major Bleeding in each arm of the Amplify study?
What is 0.6% in the Eliquis arm and 1.8% in the Enoxaparin/Warfarin arm
300
In the Xarelto P.I., the absolute bioavailability for the 10 mg tablet taken in a fasting state is 80-100%. What is it for the 20 mg tablet?
What is approxiamately 66%
300
What is the major difference between Venous thrombi, and Arterial clots?
What is Venous thrombi tend to include more red blood cells and fewer platelets (termed red clots)
300
What % of patients in AMPLIFY had unprovoked DVT or PE at baseline?
What is 90%
400
Arixtra
What is Fondaparinux
400
What are the instructions in the Pradaxa P.I. for switching patients from warfarin to Pradaxa?
What is For CrCl>50 mL/min, start warfarin 3 days before discontinuing Pradaxa For CrCl 30-50 mL/min, start warfarin 2 days before discontinuing Pradaxa For CrCL 15-30 mL/min, start warfarin 1 day before discontinuing Pradaxa For CrCl<15 mL/min, no recommendation can be made.
400
What is the dosing regimen for Treatment of DVT/PE in the Eliquis P.I.?
What is 10 mg BID for 7 days then 5 mg BID for the remainder of treatment
400
Name 2 deep veins below the knee
What is Anterior tibial, posterior tibial, or peroneal (fibular)
400
What was the number of major bleeding events occurring in each of the 3 arms of the AMPLIFY EXT study?
What is 2 in the Eliquis 2.5 mg arm, 1 in the Eliquis 5 mg arm and 4 in the placebo arm
500
Fragmin
What is Dalteparin
500
In which P.I. will not find any mention of a prophylaxis of DVT following Hip/Knee Replacement Surgery Indication?
What is Pradaxa
500
In the Xarelto P.I. what is the dosing regimen for the Treatment of DVT/PE?
What is 15 mg bid for 21 days then 20 mg qd for the remainder of therapy
500
How does abnormal blood flow promote thrombus formation?
What is Stasis brings platelets into contact with the endothelium and causes an imbalance between clotting factors and inhibitors
500
What was the treatment period for the AMPLIFY and AMPLIFY EXT studies?
What is AMPLIFY-6 months and AMPLIFY EXT 1 YEAR
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