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Disease seen most often in alcoholics and results in corpus callosum damage. It may present with sudden onset of stupor or coma and seizures. Other patients have acute, subacute, or chronic onset of dementia, gait problems, psychiatric disturbances, incontinence, hemiparesis, aphasia, and apraxia of the left hand (due to callosal disconnection).
What is Marchiafava-Bignami disease?