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PM has paranoid schizophrenia, diabetes, CKD and history of elevated LFTs. He has done well on paliperidone 9mg daily for several years with minimal side effects. He now presents with significant cog wheeling, slowed movement and masked facies. What laboratory test would be most important to assess?
CrCl - paliperidone is the only renally eliminated AP and requires dose adjustment based on renal function
50-80mL/min max dose 6mg
10-50mL/min max dose 3mg