More Extensive Regulatory System
The region at which proteins bind that initiate transcription is known as the ________.
Promoter region
This is the most studied Activator
What is Gal4?
What is another name for gene silencing?
transcriptional silencing
In most eukaryotic cases, proteins bind as ______ and use an ________ to recognize specific DNA sequences.
dimers and alpha helix
In the absence of the initiating signal, the inheritance of gene expression patterns is called _______.
epigenetic regulation
What is the stretch of DNA called that composed the complete collection of regulator binding site for a given gene?
Regulatory Sequence
Proteins that contain 60 amino acids and a helix-turn-helix structure
What is Homeodomain proteins?
What is the most common form of chromatin associated with gene silencing?
heterochromatin
In most cases, eukaryotes bind DNA as what kind of dimer?
heterodimers
What is the DNA methylase that modifies hemimethylated DNA?
maintenance methylases
What blocks activation of the promoter?
Insulators
Proteins that bind to minor groove and alter the conformation of DNA
telomeres and centromeres
________ is a class of helix-turn-DNA-binding domains and recognizes DNA in eukaryotes in similarly to the way it recognizes proteins in bacteria.
homeodomain
__________ is established in an infected cell in response to bad conditions related to its growth.
lysogenic gene expression
Binding sites are group in units called?
Enhancers
Eukaryotic activators have separate DNA-binding domain and
What is activation domain?
What are the mechanisms of gene silencing?
histone modification, DNA methylation
HMG proteins interact with the minor groove of DNA using what kind of peptide motifs?
AT hooks
What mechanism may be the primary marker of regions of genomes that are silenced?
DNA methylation
Multicellular organisms, regulatory sequences can spread _____?
Upstream & Downstream
Activators lead to the recruitment of nucleosomes modifiers, Factors needed for initiation or elongation, and ...
What is Transcriptional machinery?
What enzymes are responsible for the forward and reverse reaction in histone modification?
forward: histone methyltransferase (HMT); reverse: histone demethylase (HDM)
What are the two zinc-containing DNA-binding domains discussed in the eukaryotic transcription chapter?
zinc finger and zinc cluster
What is the two steps in the strategy for repressor synthesis of epigenetic control?
First step: synthesis is established through activation the repressor gene by the activator CII. Second step: repressor synthesis is maintained by autoregulation.