Goals & Modalities of Cancer Treatment
Offered when the patient is expected to have the greatest change of disease eradication.
What is curative therapy?
Cytokines, Vaccines, and monoclonal antibodies
What are types of immunotherapy?
Stem cells are acquired from a donor who is a HLA match to recipient
What is a allogenic transplant?
To eliminate or reduce the number of cancer cells in the primary tumor and metastatic tumor sites.
What is the goal of Chemotherapy?
The only insulin that can be given IV?
What is regular insulin?
When cancers that cannot be completely eradicated but are responsive to anticancer therapies and controlled for long periods.
What is control therapy?
The most successful type of immunotherapy and end in -mab.
What are monoclonal antibodies?
What is a syngeneic transplant?
Biopatches, alcohol impregnated swab caps, daily CHG baths, sterile routine dressing changes, and hand hygiene
What are precautions taken to prevent CLABSI?
Device inserted into the body's central venous system to enable the administration of fluids, blood products, medication, or other therapies.
What is a central venous access device?
Absence of all symptoms of the disease
What is remission?
Cell surface, intracellular, or extracellular
What are sites that targeted therapy works on?
Patients receive their own stem cells back following myeloablative chemotherapy
What is autologous stem cell transplant?
dysuria, urinary frequency, hematuria, cystitis, urinary tract infection, and bladder spasms
What are the side effects of intravesical bladder chemotherapy?
Leakage of fluid out of the vessel into the surrounding tissue causing inflammation and irritation
What is a extravasation?
Goal is to keep the patient comfortable rather than curing or controlling.
What is palliative therapy?
Corticosteroids, Estrogen Receptor Blockers, Estrogen Receptor Modulator, Aromatase Inhibitors, Estrogens, Androgen Receptor Blockers
What are types of Hormone therapy?
filgrastim (neupogen), pegfilgrastim (Neulasta), tbo-filgrastim (Granix)
What are granulocyte colony-stimulating factors? (Used to treat chemotherapy induced neutropenia).
Have their effect on the cells during all phases of the cell cycle, including the process of cell replication and proliferation and the resting phase.
What are cell phase-nonspecific chemotherapy drugs?
Aplastic anemia, Severe Sickle Cell disease, Ovarian Cancer, Testicular Cancer are a few examples
What are indications for Hematopoietic Stem Cell Transplant?
Used as preventative, diagnostic, curative, supportive, rehabilitative, or palliative therapy for cancer.
What is surgery?
Overexpressed in certain cancer, especially breast cancers, and is associated with more aggressive disease and decreased survival
What is HER-2?
T lymphocytes from donor stem cells recognize recipient as foreign
What is graft-vs-host disease?
Oral, intramuscular, IV, intra-cavitary, topical, intrathecal, intra-arterial, perfusion, or subcutaneous
What are methods of chemotherapy administration?
Myeloablative dosages of chemo with or without adjunctive radiation to treat the underlying disease
What is a conditioning regimen?